SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		4 / 6 LEU A  89
VAL A  92
VAL A 128
ASP A 106
 None
 1.16A 1dz4A-1xp8A:
undetectable		 1dz4A-1xp8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ILE A  76
ALA A  88
LEU A  89
LEU A 111
ILE A 204
 None
 1.18A 1g5yB-1xp8A:
undetectable		 1g5yB-1xp8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ASP A  60
ILE A  68
PRO A  69
ILE A 202
ALA A  88
 None
 1.26A 1kijB-1xp8A:
undetectable		 1kijB-1xp8A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		4 / 5 ASP A  60
SER A  58
ASP A 334
GLN A  94
 None
 1.46A 1n2xB-1xp8A:
2.6		 1n2xB-1xp8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A  63
LEU A 235
LEU A  87
ALA A  88
ILE A  91
 None
 1.13A 2bxpA-1xp8A:
undetectable		 2bxpA-1xp8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 PHE A 203
PRO A  69
ILE A 204
VAL A 155
LEU A 227
 None
 1.19A 2zzmA-1xp8A:
1.3		 2zzmA-1xp8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 11 THR A  54
ILE A  76
LEU A 273
LEU A 235
ILE A 257
 None
 1.31A 3a50B-1xp8A:
undetectable		 3a50B-1xp8A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 11 THR A  54
ILE A  76
LEU A 273
LEU A 235
ILE A 257
 None
 1.31A 3a50C-1xp8A:
undetectable		 3a50C-1xp8A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		4 / 6 LEU A  89
VAL A  92
VAL A 128
ASP A 106
 None
 1.13A 3fwgA-1xp8A:
undetectable		 3fwgA-1xp8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ILE A  76
GLN A  94
LEU A 273
VAL A 237
THR A  74
 None
 1.10A 3ix9B-1xp8A:
2.2		 3ix9B-1xp8A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		4 / 6 GLY A  55
THR A  54
LEU A  59
ASP A 286
 None
 0.99A 3ps9A-1xp8A:
2.3		 3ps9A-1xp8A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		3 / 3 ASN A 133
GLU A 135
ARG A 164
 None
 0.96A 3wxoA-1xp8A:
undetectable		 3wxoA-1xp8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A  88
ILE A  91
ASN A 262
LEU A  63
GLY A  66
 None
 1.15A 4r38B-1xp8A:
undetectable		 4r38B-1xp8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A  88
ILE A  91
ASN A 262
LEU A  63
GLY A  66
 None
 1.18A 4r38C-1xp8A:
undetectable		 4r38C-1xp8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A  88
ILE A  91
ASN A 262
LEU A  63
GLY A  66
 None
 1.20A 4r38D-1xp8A:
undetectable		 4r38D-1xp8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 THR A 259
LEU A  87
THR A  74
GLY A  78
PRO A  79
 None
 0.93A 4ypmA-1xp8A:
undetectable		 4ypmA-1xp8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 11 THR A  86
ALA A  93
GLY A 120
ALA A 116
ASP A 112
 AGS  A 400 (-3.9A)
None
None
None
AGS  A 400 (-3.6A)
 1.34A 5bxnV-1xp8A:
undetectable
5bxnW-1xp8A:
undetectable		 5bxnV-1xp8A:
19.84
5bxnW-1xp8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		4 / 6 TYR A 304
ILE A 296
VAL A 288
ALA A 291
 None
 0.90A 5cu6A-1xp8A:
undetectable		 5cu6A-1xp8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 THR A  86
ALA A  93
GLY A 120
ALA A 116
ASP A 112
 AGS  A 400 (-3.9A)
None
None
None
AGS  A 400 (-3.6A)
 1.37A 5l5zH-1xp8A:
undetectable
5l5zI-1xp8A:
undetectable		 5l5zH-1xp8A:
19.63
5l5zI-1xp8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 THR A  86
ALA A  93
GLY A 120
ALA A 116
ASP A 112
 AGS  A 400 (-3.9A)
None
None
None
AGS  A 400 (-3.6A)
 1.38A 5l5zV-1xp8A:
undetectable
5l5zW-1xp8A:
undetectable		 5l5zV-1xp8A:
19.63
5l5zW-1xp8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 138
PHE A 203
ILE A 105
ALA A 103
GLY A  71
 None
 0.94A 5veuA-1xp8A:
0.0		 5veuA-1xp8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 9 ASN A 262
VAL A 264
LEU A 235
GLY A  67
LEU A  63
 None
 1.34A 6czmA-1xp8A:
undetectable
6czmB-1xp8A:
undetectable		 6czmA-1xp8A:
24.30
6czmB-1xp8A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1xp8 RECA PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A  62
GLY A  67
ILE A  68
LEU A 290
VAL A 271
 None
 0.94A 6dh0B-1xp8A:
undetectable		 6dh0B-1xp8A:
11.48