SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xpo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 11 ALA A 357
ALA A 182
LEU A 208
LEU A 188
GLN A 189
 None
AGS  A1600 (-4.5A)
None
None
None
 1.13A 1rlbF-1xpoA:
0.0		 1rlbF-1xpoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		4 / 8 LEU A  26
ALA A  37
ILE A  38
GLY A  22
 None
 0.80A 1sv9A-1xpoA:
undetectable		 1sv9A-1xpoA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 12 ALA A 159
ARG A 144
LEU A 263
ILE A 261
MET A 219
 None
 1.41A 1y0xX-1xpoA:
undetectable		 1y0xX-1xpoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 10 MET A 219
TYR A  72
LEU A 207
VAL A 206
LEU A 208
 None
 1.42A 2w98A-1xpoA:
undetectable		 2w98A-1xpoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		3 / 3 GLU A 368
GLU A 369
TRP A 381
 None
 0.86A 3hrdA-1xpoA:
undetectable
3hrdE-1xpoA:
undetectable
3hrdF-1xpoA:
undetectable		 3hrdA-1xpoA:
22.53
3hrdE-1xpoA:
22.53
3hrdF-1xpoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 11 ASP A 328
ALA A 317
THR A 268
ILE A 267
ARG A 212
 None
None
None
None
AGS  A1600 ( 3.2A)
 1.42A 3n23A-1xpoA:
2.9		 3n23A-1xpoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 12 VAL A  54
ASP A  52
TYR A  72
ILE A 101
ILE A  35
 None
 1.21A 4eb6B-1xpoA:
undetectable
4eb6C-1xpoA:
3.4		 4eb6B-1xpoA:
23.64
4eb6C-1xpoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 8 GLU A 248
LEU A 264
VAL A 260
LEU A 313
GLY A 302
 None
 1.49A 4r3aA-1xpoA:
undetectable		 4r3aA-1xpoA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		4 / 8 ILE A 176
LEU A 145
ILE A 191
MET A 341
 None
 0.97A 4xtaB-1xpoA:
undetectable		 4xtaB-1xpoA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 12 GLY A 171
ILE A 168
THR A 314
ILE A 261
GLY A 302
 None
 0.87A 5d4uD-1xpoA:
undetectable		 5d4uD-1xpoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 10 LEU A  55
LEU A 113
ILE A  57
SER A  82
GLY A  61
 None
None
None
U  G   1 ( 3.2A)
None
 1.30A 6dm0B-1xpoA:
2.0
6dm0C-1xpoA:
2.3		 6dm0B-1xpoA:
10.92
6dm0C-1xpoA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xpo RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		3 / 3 LEU A  39
ASN A   8
LEU A  14
 None
 0.62A 6exiA-1xpoA:
undetectable		 6exiA-1xpoA:
10.92