SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1xpw LOC51668 PROTEIN
(Homo
sapiens) 		4 / 8 PHE A 125
PHE A  45
SER A  20
ALA A 121
 None
 1.16A 1rqpC-1xpwA:
undetectable		 1rqpC-1xpwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1xpw LOC51668 PROTEIN
(Homo
sapiens) 		4 / 8 PHE A 125
PHE A  45
SER A  20
ALA A 121
 None
 1.15A 1rqpA-1xpwA:
undetectable		 1rqpA-1xpwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1xpw LOC51668 PROTEIN
(Homo
sapiens) 		4 / 6 ALA A 133
SER A 132
ILE A   4
ASP A   5
 None
 1.02A 1yc2A-1xpwA:
undetectable		 1yc2A-1xpwA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1xpw LOC51668 PROTEIN
(Homo
sapiens) 		4 / 8 PHE A 125
PHE A  45
SER A  20
ALA A 121
 None
 1.12A 2v7uA-1xpwA:
undetectable		 2v7uA-1xpwA:
20.68