SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Trypanosoma
cruzi) 		4 / 7 THR A  34
LEU A  90
VAL A 128
ASP A  86
 None
 1.07A 2cppA-1xq7A:
undetectable		 2cppA-1xq7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Trypanosoma
cruzi) 		4 / 5 PHE A  38
PHE A 113
PHE A  55
VAL A   8
 None
 1.27A 2lh6A-1xq7A:
undetectable		 2lh6A-1xq7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 TYR A  50
GLY A  52
PHE A  69
 None
 0.65A 2m2pB-1xq7A:
undetectable		 2m2pB-1xq7A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Trypanosoma
cruzi) 		4 / 5 ILE A  64
ASP A 138
GLU A 144
VAL A  96
 None
 1.23A 4nkxD-1xq7A:
undetectable		 4nkxD-1xq7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Trypanosoma
cruzi) 		4 / 6 PHE A  55
ILE A  12
ASP A  16
GLY A  15
 None
 0.97A 5x5qE-1xq7A:
undetectable		 5x5qE-1xq7A:
18.77