SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		3 / 3 ASP A  83
VAL A  87
PRO A  90
 P6G  A 502 (-3.2A)
None
None
 0.70A 2avvA-1xqaA:
undetectable		 2avvA-1xqaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		4 / 4 LEU A   8
THR A   9
ILE A  46
HIS A   5
 None
 1.26A 2jfaB-1xqaA:
undetectable		 2jfaB-1xqaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		4 / 8 LEU A  80
LEU A  20
VAL A  63
GLY A  64
 None
 0.97A 2po5B-1xqaA:
undetectable		 2po5B-1xqaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		4 / 8 LEU A   6
LEU A  20
ALA A  16
PHE A 106
 None
 0.86A 2vcvF-1xqaA:
undetectable		 2vcvF-1xqaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		4 / 8 LEU A   8
LEU A   6
LEU A  26
PHE A  65
 None
 0.85A 2vcvF-1xqaA:
undetectable		 2vcvF-1xqaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		4 / 8 LEU A   6
LEU A  20
ALA A  16
PHE A 106
 None
 0.80A 2vcvP-1xqaA:
undetectable		 2vcvP-1xqaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		4 / 8 LEU A   8
LEU A   6
LEU A  26
PHE A  65
 None
 0.83A 2vcvP-1xqaA:
undetectable		 2vcvP-1xqaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		5 / 9 PHE A  98
VAL A  87
ASN A  77
ILE A  76
PHE A  19
 None
None
None
P6G  A 502 ( 4.9A)
None
 1.14A 3t3rB-1xqaA:
undetectable		 3t3rB-1xqaA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN
(Bacillus
cereus) 		4 / 7 LEU A  20
GLY A 104
GLY A 105
ALA A 102
 None
 0.57A 4yjiA-1xqaA:
undetectable		 4yjiA-1xqaA:
12.93