SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 7 PHE A  76
VAL A  38
ILE A 148
GLY A  47
 None
 0.79A 11gsA-1xqpA:
undetectable		 11gsA-1xqpA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 6 LEU A 126
ASP A 121
MET A  52
LEU A  56
 None
 1.26A 1errB-1xqpA:
undetectable		 1errB-1xqpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		5 / 9 GLY A 236
ILE A 242
ALA A 227
VAL A 228
PHE A 245
 None
 1.16A 2drdA-1xqpA:
undetectable		 2drdA-1xqpA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  76
VAL A  38
ILE A 148
GLY A  47
 None
 0.88A 2gssA-1xqpA:
undetectable		 2gssA-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  76
VAL A  38
ILE A 148
GLY A  47
 None
 0.88A 2gssB-1xqpA:
undetectable		 2gssB-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 5 LEU A 126
ASP A 121
MET A  52
LEU A  56
 None
 1.24A 2jfaA-1xqpA:
undetectable		 2jfaA-1xqpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 5 LEU A 126
ASP A 121
MET A  52
LEU A  56
 None
 1.26A 2qxsA-1xqpA:
undetectable		 2qxsA-1xqpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 5 LEU A 126
ASP A 121
MET A  52
LEU A  56
 None
 1.24A 2qxsB-1xqpA:
undetectable		 2qxsB-1xqpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 7 PHE A  76
VAL A  38
ILE A 148
GLY A  47
 None
 0.75A 3gssA-1xqpA:
undetectable		 3gssA-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 7 PHE A  76
VAL A  38
ILE A 148
GLY A  47
 None
 0.75A 3gssB-1xqpA:
undetectable		 3gssB-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  76
VAL A  38
ILE A 148
GLY A  47
 None
 0.82A 3hjoA-1xqpA:
undetectable		 3hjoA-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  76
VAL A  38
VAL A  81
GLY A  47
 None
 0.81A 3hjoA-1xqpA:
undetectable		 3hjoA-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  76
VAL A  38
ILE A 148
GLY A  47
 None
 0.80A 3hjoB-1xqpA:
undetectable		 3hjoB-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  76
VAL A  38
VAL A  81
GLY A  47
 None
 0.80A 3hjoB-1xqpA:
undetectable		 3hjoB-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		5 / 10 PHE A  76
VAL A  38
VAL A  81
ILE A 148
GLY A  47
 None
 1.18A 3km6A-1xqpA:
undetectable		 3km6A-1xqpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 7 PHE A  76
VAL A  38
VAL A  81
GLY A  47
 None
 0.79A 3kmoB-1xqpA:
undetectable		 3kmoB-1xqpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 8 PHE A  76
VAL A  38
ILE A 148
GLY A  47
 None
 0.91A 3n9jA-1xqpA:
undetectable		 3n9jA-1xqpA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		3 / 3 ALA A 227
VAL A 228
GLN A 246
 None
 0.75A 3of4B-1xqpA:
undetectable		 3of4B-1xqpA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		3 / 3 ARG A 195
VAL A 175
THR A 179
 None
 0.87A 3pwrA-1xqpA:
undetectable		 3pwrA-1xqpA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 167
GLY A 123
VAL A 133
MET A  52
LEU A 149
 None
 1.13A 4a81A-1xqpA:
undetectable		 4a81A-1xqpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 6 TYR A  71
TRP A  69
PHE A  72
PHE A  76
 None
8HG  A 257 (-4.5A)
None
None
 0.85A 4awuA-1xqpA:
0.0		 4awuA-1xqpA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 5 ALA A 207
THR A 210
VAL A  10
ILE A  11
 None
 0.96A 4xe3A-1xqpA:
undetectable		 4xe3A-1xqpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 5 ALA A 207
THR A 210
VAL A  10
ILE A  11
 None
 0.82A 4xe3B-1xqpA:
undetectable		 4xe3B-1xqpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		5 / 12 THR A 125
LEU A 122
PRO A 213
ARG A 157
TYR A 153
 None
 1.18A 5dlvA-1xqpA:
undetectable		 5dlvA-1xqpA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1xqp 8-OXOGUANINE DNA
GLYCOSYLASE
(Pyrobaculum
aerophilum) 		4 / 6 PHE A 245
LEU A 244
ALA A 182
THR A 210
 None
 0.86A 6f88A-1xqpA:
undetectable		 6f88A-1xqpA:
13.74