SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 235
ASP A 197
MET A 273
LEU A 280
 None
 0.96A 1errB-1xqsA:
undetectable		 1errB-1xqsA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		4 / 6 ALA C 270
SER C 254
ARG C 301
LEU C 274
 None
 0.98A 1gahA-1xqsC:
undetectable		 1gahA-1xqsC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		4 / 6 GLY A 185
GLN A 182
VAL A 150
ALA A 188
 None
 0.95A 1p6kA-1xqsA:
undetectable		 1p6kA-1xqsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 248
LEU A 195
ALA A 208
ALA A 238
VAL A 234
 None
 1.10A 1sa1A-1xqsA:
undetectable
1sa1B-1xqsA:
undetectable		 1sa1A-1xqsA:
20.54
1sa1B-1xqsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 248
LEU A 195
ALA A 208
ALA A 238
VAL A 234
 None
 1.08A 1sa1C-1xqsA:
undetectable
1sa1D-1xqsA:
undetectable		 1sa1C-1xqsA:
20.54
1sa1D-1xqsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 232
LEU A 209
MET A 239
LEU A 296
 None
 1.36A 1skxA-1xqsA:
0.0		 1skxA-1xqsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP C 206
GLY C 224
ASP C 225
GLY C 203
ASP C 232
 None
 1.29A 2fqyA-1xqsC:
undetectable		 2fqyA-1xqsC:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 226
VAL A 216
PHE A 288
VAL A 292
LEU A 235
 None
 1.20A 2ft9A-1xqsA:
undetectable		 2ft9A-1xqsA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 197
ARG A 194
ARG A 198
 None
 1.00A 2j9dA-1xqsA:
undetectable
2j9dC-1xqsA:
undetectable		 2j9dA-1xqsA:
20.24
2j9dC-1xqsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 344
LEU A 293
GLY A 294
VAL A 274
THR A 301
 None
 1.13A 2q7lA-1xqsA:
undetectable		 2q7lA-1xqsA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 296
VAL A 274
GLY A 306
THR A 301
 None
 0.81A 2wd9A-1xqsA:
undetectable		 2wd9A-1xqsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		3 / 3 THR A 347
SER A 298
LYS A 265
 None
 0.70A 3aocC-1xqsA:
undetectable		 3aocC-1xqsA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL C 238
THR C 295
THR C 265
ARG C 264
 None
 1.19A 3bjwA-1xqsC:
0.0		 3bjwA-1xqsC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE C 198
PHE C 205
THR C 341
VAL C 346
 None
 1.31A 3lb3A-1xqsC:
1.4		 3lb3A-1xqsC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		5 / 12 GLN A 225
VAL A 216
GLY A 222
ALA A 211
ALA A 208
 None
 0.98A 3sufB-1xqsA:
undetectable		 3sufB-1xqsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
HSPBP1 PROTEIN
(Homo
sapiens) 		4 / 6 ARG C 264
ASN A 133
ASP A 139
GLY A  88
 None
 1.07A 4l1aB-1xqsC:
undetectable		 4l1aB-1xqsC:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 234
LEU A 154
VAL A 204
ALA A 208
LEU A 215
 None
 1.01A 4m11C-1xqsA:
undetectable		 4m11C-1xqsA:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		9 / 10 GLY C 201
GLY C 230
LYS C 271
ARG C 272
SER C 275
GLY C 339
SER C 340
ARG C 342
ILE C 343
 AMP  C 401 ( 3.9A)
AMP  C 401 (-3.6A)
AMP  C 401 (-3.2A)
AMP  C 401 (-3.4A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
AMP  C 401 (-4.7A)
 1.05A 5aqfA-1xqsC:
4.2		 5aqfA-1xqsC:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		10 / 10 GLY C 202
GLY C 230
GLU C 268
LYS C 271
ARG C 272
SER C 275
GLY C 339
SER C 340
ARG C 342
ILE C 343
 AMP  C 401 (-3.7A)
AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.2A)
AMP  C 401 (-3.4A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
AMP  C 401 (-4.7A)
 0.72A 5aqfA-1xqsC:
4.2		 5aqfA-1xqsC:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		7 / 10 GLY C 229
GLY C 230
GLU C 268
LYS C 271
SER C 275
SER C 340
ILE C 343
 None
AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.2A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.3A)
AMP  C 401 (-4.7A)
 1.42A 5aqfA-1xqsC:
4.2		 5aqfA-1xqsC:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		6 / 10 GLY C 230
GLU C 268
ARG C 272
GLY C 339
SER C 340
ARG C 342
 AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
 1.43A 5aqfA-1xqsC:
4.2		 5aqfA-1xqsC:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		9 / 10 GLY C 201
GLY C 230
LYS C 271
ARG C 272
SER C 275
GLY C 339
SER C 340
ARG C 342
ILE C 343
 AMP  C 401 ( 3.9A)
AMP  C 401 (-3.6A)
AMP  C 401 (-3.2A)
AMP  C 401 (-3.4A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
AMP  C 401 (-4.7A)
 1.07A 5aqfC-1xqsC:
4.0		 5aqfC-1xqsC:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		10 / 10 GLY C 202
GLY C 230
GLU C 268
LYS C 271
ARG C 272
SER C 275
GLY C 339
SER C 340
ARG C 342
ILE C 343
 AMP  C 401 (-3.7A)
AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.2A)
AMP  C 401 (-3.4A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
AMP  C 401 (-4.7A)
 0.74A 5aqfC-1xqsC:
4.0		 5aqfC-1xqsC:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		7 / 10 GLY C 229
GLY C 230
GLU C 268
LYS C 271
SER C 275
SER C 340
ILE C 343
 None
AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.2A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.3A)
AMP  C 401 (-4.7A)
 1.41A 5aqfC-1xqsC:
4.0		 5aqfC-1xqsC:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		6 / 10 GLY C 230
GLU C 268
ARG C 272
GLY C 339
SER C 340
ARG C 342
 AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
 1.45A 5aqfC-1xqsC:
4.0		 5aqfC-1xqsC:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		9 / 10 GLY C 201
GLY C 230
LYS C 271
ARG C 272
SER C 275
GLY C 339
SER C 340
ARG C 342
ILE C 343
 AMP  C 401 ( 3.9A)
AMP  C 401 (-3.6A)
AMP  C 401 (-3.2A)
AMP  C 401 (-3.4A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
AMP  C 401 (-4.7A)
 1.04A 5aqyA-1xqsC:
3.2		 5aqyA-1xqsC:
50.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		10 / 10 GLY C 202
GLY C 230
GLU C 268
LYS C 271
ARG C 272
SER C 275
GLY C 339
SER C 340
ARG C 342
ILE C 343
 AMP  C 401 (-3.7A)
AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.2A)
AMP  C 401 (-3.4A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
AMP  C 401 (-4.7A)
 0.72A 5aqyA-1xqsC:
3.2		 5aqyA-1xqsC:
50.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		7 / 10 GLY C 229
GLY C 230
GLU C 268
LYS C 271
SER C 275
SER C 340
ILE C 343
 None
AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.2A)
AMP  C 401 (-2.8A)
AMP  C 401 (-3.3A)
AMP  C 401 (-4.7A)
 1.44A 5aqyA-1xqsC:
3.2		 5aqyA-1xqsC:
50.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		6 / 10 GLY C 230
GLU C 268
ARG C 272
GLY C 339
SER C 340
ARG C 342
 AMP  C 401 (-3.6A)
AMP  C 401 (-3.0A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.4A)
AMP  C 401 (-3.3A)
None
 1.46A 5aqyA-1xqsC:
3.2		 5aqyA-1xqsC:
50.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 193
LEU A 215
PHE A 226
LEU A 253
 None
 0.89A 5gs4A-1xqsA:
undetectable		 5gs4A-1xqsA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1xqs HEAT SHOCK 70 KDA
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE C 233
GLY C 201
GLY C 339
ILE C 343
LEU C 237
 None
AMP  C 401 ( 3.9A)
AMP  C 401 (-3.4A)
AMP  C 401 (-4.7A)
None
 1.20A 5ul4A-1xqsC:
undetectable		 5ul4A-1xqsC:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xqs HSPBP1 PROTEIN
(Homo
sapiens) 		3 / 3 GLN A 167
TRP A 163
VAL A 204
 None
 1.18A 6auuA-1xqsA:
undetectable		 6auuA-1xqsA:
20.00