SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 10 GLU A  84
GLU A  85
ALA A  88
LEU A  89
MET A  32
 None
 1.37A 1a29A-1xqwA:
undetectable		 1a29A-1xqwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 126
VAL A  58
LEU A  48
MET A 274
TYR A 281
 None
 1.44A 1p5zB-1xqwA:
2.2		 1p5zB-1xqwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		3 / 3 ARG A  68
TYR A  18
LYS A  20
 None
 1.01A 1uujB-1xqwA:
undetectable		 1uujB-1xqwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 GLY A 107
GLY A 108
SER A 133
LEU A 112
HIS A 271
 None
None
None
None
LEU  A 301 (-3.4A)
 1.34A 1ya4B-1xqwA:
5.1		 1ya4B-1xqwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A  86
GLU A  85
LEU A  89
GLY A 103
LEU A 101
 None
 1.00A 2jfaB-1xqwA:
undetectable		 2jfaB-1xqwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 MET A 141
ALA A 111
LEU A 112
ALA A 113
MET A 208
 PHE  A 300 ( 4.9A)
None
None
None
None
 1.30A 2jjpA-1xqwA:
undetectable		 2jjpA-1xqwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		3 / 3 HIS A 292
ILE A 126
LEU A 284
 None
 0.62A 2kceA-1xqwA:
undetectable		 2kceA-1xqwA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 126
VAL A  58
LEU A  48
MET A 274
TYR A 281
 None
 1.41A 2no0B-1xqwA:
2.1		 2no0B-1xqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		3 / 3 SER A 104
HIS A 264
ASP A 287
 LEU  A 301 (-3.3A)
None
None
 0.79A 2wa2B-1xqwA:
undetectable		 2wa2B-1xqwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 4 GLU A  27
GLY A  55
THR A  52
GLU A  54
 None
 1.22A 3e9xA-1xqwA:
undetectable		 3e9xA-1xqwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 6 VAL A 127
ILE A 232
ILE A 238
LEU A 237
 None
 0.65A 3hegA-1xqwA:
undetectable		 3hegA-1xqwA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 HIS A 271
ASP A 244
GLY A  36
ALA A 105
SER A  47
 LEU  A 301 (-3.4A)
None
LEU  A 301 (-3.2A)
PHE  A 300 ( 3.0A)
None
 1.06A 3sudA-1xqwA:
undetectable		 3sudA-1xqwA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 HIS A 271
ASP A 244
GLY A  36
ALA A 105
SER A  47
 LEU  A 301 (-3.4A)
None
LEU  A 301 (-3.2A)
PHE  A 300 ( 3.0A)
None
 0.91A 3sudB-1xqwA:
undetectable		 3sudB-1xqwA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 8 HIS A  35
LYS A 194
SER A 195
TYR A 198
 None
 0.87A 4bjcA-1xqwA:
undetectable		 4bjcA-1xqwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_B_KANB401_1
(APH(2')-ID)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 10 ASP A  43
SER A  41
ASP A  62
HIS A  42
GLU A 200
 None
 1.30A 4dfbB-1xqwA:
undetectable		 4dfbB-1xqwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 GLU A 245
PHE A 177
ILE A 254
LEU A 263
GLY A 129
 LEU  A 301 ( 4.6A)
None
None
None
None
 1.49A 4djfB-1xqwA:
undetectable		 4djfB-1xqwA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 8 HIS A  35
LYS A 194
SER A 195
TYR A 198
 None
 0.72A 4hyfB-1xqwA:
undetectable		 4hyfB-1xqwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 8 HIS A  35
LYS A 194
SER A 195
TYR A 198
 None
 0.73A 4hyfC-1xqwA:
undetectable		 4hyfC-1xqwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 6 TYR A 281
ASN A 282
LEU A  46
PHE A  60
 None
 1.31A 4twdI-1xqwA:
undetectable
4twdJ-1xqwA:
undetectable		 4twdI-1xqwA:
20.71
4twdJ-1xqwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 11 LEU A 110
ALA A 109
VAL A 127
THR A 236
ILE A 234
 None
 1.25A 4uuuB-1xqwA:
undetectable		 4uuuB-1xqwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 8 ASN A 282
PHE A  60
GLU A 191
THR A 239
 None
 1.36A 5hqaA-1xqwA:
undetectable		 5hqaA-1xqwA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A 284
ASP A 244
GLY A 241
PHE A 266
ALA A 105
 None
None
None
None
PHE  A 300 ( 3.0A)
 1.30A 5j7wC-1xqwA:
undetectable		 5j7wC-1xqwA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		6 / 12 GLY A 108
GLY A 124
GLY A 103
LYS A  98
HIS A 121
ILE A 234
 None
 1.31A 5m5bA-1xqwA:
undetectable		 5m5bA-1xqwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 6 ILE A 225
ALA A 109
LEU A 112
ILE A 254
 None
 0.73A 5mvmB-1xqwA:
undetectable
5mvmC-1xqwA:
undetectable		 5mvmB-1xqwA:
11.70
5mvmC-1xqwA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 1xqw PROLINE
IMINOPEPTIDASE
(Thermoplasma
acidophilum) 		4 / 6 GLY A 129
SER A 132
THR A 137
VAL A 246
 None
None
PHE  A 300 (-3.9A)
None
 1.21A 5ysiA-1xqwA:
0.0		 5ysiA-1xqwA:
17.35