SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP2_B_PNNB5002_0 (TRANSCRIPTIONAL REGULATOR TCAR)	1xr0	FGFR SIGNALLING ADAPTOR SNT-1 (Homo sapiens)	4 / 5	ASN B 70 ALA B 94 ALA B 92 ARG B 93	None	1.40A	3kp2B-1xr0B: undetectable	3kp2B-1xr0B: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_D_ZPCD1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	1xr0	FGFR SIGNALLING ADAPTOR SNT-1 (Homo sapiens)	4 / 7	GLU B 44 ILE B 46 GLU B 39 VAL B 13	None	1.08A	4a97D-1xr0B: undetectable	4a97D-1xr0B: 16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_H_ZPCH1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	1xr0	FGFR SIGNALLING ADAPTOR SNT-1 (Homo sapiens)	4 / 7	GLU B 44 ILE B 46 GLU B 39 VAL B 13	None	1.07A	4a97H-1xr0B: undetectable	4a97H-1xr0B: 16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESE_A_TPFA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1xr0	BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 FGFR SIGNALLING ADAPTOR SNT-1 (Homo sapiens)	4 / 8	LEU B 71 ILE B 24 GLY B 30 LEU A 417	None	0.90A	5eseA-1xr0B: undetectable	5eseA-1xr0B: 13.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3KP2_B_PNNB5002_0","TRANSCRIPTIONAL REGULATOR TCAR","1xr0","FGFR SIGNALLING ADAPTOR SNT-1","Homo sapiens",4,"ASN B  70;ALA B  94;ALA B  92;ARG B  93","None","1.40A","3kp2B-1xr0B:undetectable","3kp2B-1xr0B:23.81"],["4A97_D_ZPCD1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","1xr0","FGFR SIGNALLING ADAPTOR SNT-1","Homo sapiens",4,"GLU B  44;ILE B  46;GLU B  39;VAL B  13","None","1.08A","4a97D-1xr0B:undetectable","4a97D-1xr0B:16.01"],["4A97_H_ZPCH1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","1xr0","FGFR SIGNALLING ADAPTOR SNT-1","Homo sapiens",4,"GLU B  44;ILE B  46;GLU B  39;VAL B  13","None","1.07A","4a97H-1xr0B:undetectable","4a97H-1xr0B:16.01"],["5ESE_A_TPFA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","1xr0","BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1;FGFR SIGNALLING ADAPTOR SNT-1","Homo sapiens",4,"LEU B  71;ILE B  24;GLY B  30;LEU A 417","None","0.90A","5eseA-1xr0B:undetectable","5eseA-1xr0B:13.40"]]