SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 10 GLY A 273
ALA A 280
THR A 272
THR A 406
ALA A 251
 None
 1.25A 1gtnO-1xr4A:
undetectable
1gtnP-1xr4A:
undetectable		 1gtnO-1xr4A:
11.26
1gtnP-1xr4A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 9 GLY A 273
ALA A 280
THR A 272
THR A 406
ALA A 251
 None
 1.26A 1gtnQ-1xr4A:
undetectable
1gtnR-1xr4A:
undetectable		 1gtnQ-1xr4A:
11.26
1gtnR-1xr4A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 VAL A 421
LEU A 368
SER A 366
LEU A 365
THR A 423
 None
 1.04A 1kw0A-1xr4A:
undetectable		 1kw0A-1xr4A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 11 VAL A 421
LEU A 368
SER A 366
LEU A 365
THR A 423
 None
 0.98A 1mmtA-1xr4A:
undetectable		 1mmtA-1xr4A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A  81
LEU A  55
SER A  53
VAL A 198
ALA A 194
 None
 1.08A 1n5xA-1xr4A:
undetectable		 1n5xA-1xr4A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A  81
LEU A  55
SER A  53
VAL A 198
ALA A 194
 None
 1.07A 1n5xB-1xr4A:
undetectable		 1n5xB-1xr4A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 ASP A 167
GLY A 170
ALA A 191
LEU A 221
PHE A 207
 None
 1.05A 1nw3A-1xr4A:
undetectable		 1nw3A-1xr4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 7 LEU A 460
GLY A 439
THR A 436
ILE A 370
 None
 1.02A 2bdmA-1xr4A:
undetectable		 2bdmA-1xr4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		3 / 3 ALA A 277
THR A 406
PHE A 284
 None
 0.77A 2c6nB-1xr4A:
undetectable		 2c6nB-1xr4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 6 LEU A  91
VAL A 378
MET A 379
ILE A 139
 None
 1.10A 2hyyC-1xr4A:
undetectable		 2hyyC-1xr4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 6 LEU A 124
LYS A 108
GLN A 138
ILE A 115
 None
 1.18A 2jn3A-1xr4A:
undetectable		 2jn3A-1xr4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 9 LEU A 460
ILE A 250
ILE A 258
VAL A 442
ILE A 440
 None
 1.16A 2r5qA-1xr4A:
undetectable		 2r5qA-1xr4A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 9 LEU A 460
ILE A 250
ILE A 258
VAL A 442
ILE A 440
 None
 1.15A 2r5qC-1xr4A:
undetectable		 2r5qC-1xr4A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 ARG A 145
GLN A 150
ARG A 493
HIS A 140
 None
 1.39A 2vxaA-1xr4A:
undetectable
2vxaC-1xr4A:
undetectable
2vxaE-1xr4A:
undetectable		 2vxaA-1xr4A:
12.20
2vxaC-1xr4A:
12.20
2vxaE-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 GLN A 150
ARG A 145
ARG A 493
HIS A 140
 None
 1.41A 2vxaA-1xr4A:
undetectable
2vxaB-1xr4A:
undetectable
2vxaK-1xr4A:
undetectable		 2vxaA-1xr4A:
12.20
2vxaB-1xr4A:
12.20
2vxaK-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 GLN A 150
ARG A 145
ARG A 493
HIS A 140
 None
 1.39A 2vxaB-1xr4A:
undetectable
2vxaC-1xr4A:
undetectable
2vxaG-1xr4A:
undetectable		 2vxaB-1xr4A:
12.20
2vxaC-1xr4A:
12.20
2vxaG-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 ARG A 145
GLN A 150
ARG A 493
HIS A 140
 None
 1.40A 2vxaD-1xr4A:
undetectable
2vxaF-1xr4A:
undetectable
2vxaI-1xr4A:
undetectable		 2vxaD-1xr4A:
12.20
2vxaF-1xr4A:
12.20
2vxaI-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 GLN A 150
ARG A 145
ARG A 493
HIS A 140
 None
 1.39A 2vxaD-1xr4A:
undetectable
2vxaE-1xr4A:
undetectable
2vxaL-1xr4A:
undetectable		 2vxaD-1xr4A:
12.20
2vxaE-1xr4A:
12.20
2vxaL-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 ARG A 493
HIS A 140
ARG A 145
GLN A 150
 None
 1.38A 2vxaF-1xr4A:
undetectable
2vxaG-1xr4A:
undetectable
2vxaI-1xr4A:
undetectable		 2vxaF-1xr4A:
12.20
2vxaG-1xr4A:
12.20
2vxaI-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 ARG A 493
HIS A 140
GLN A 150
ARG A 145
 None
 1.38A 2vxaB-1xr4A:
undetectable
2vxaG-1xr4A:
undetectable
2vxaH-1xr4A:
undetectable		 2vxaB-1xr4A:
12.20
2vxaG-1xr4A:
12.20
2vxaH-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 GLN A 150
ARG A 145
ARG A 493
HIS A 140
 None
 1.39A 2vxaH-1xr4A:
undetectable
2vxaI-1xr4A:
undetectable
2vxaJ-1xr4A:
undetectable		 2vxaH-1xr4A:
12.20
2vxaI-1xr4A:
12.20
2vxaJ-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 ARG A 493
HIS A 140
ARG A 145
GLN A 150
 None
 1.39A 2vxaD-1xr4A:
undetectable
2vxaJ-1xr4A:
undetectable
2vxaL-1xr4A:
undetectable		 2vxaD-1xr4A:
12.20
2vxaJ-1xr4A:
12.20
2vxaL-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 ARG A 493
HIS A 140
GLN A 150
ARG A 145
 None
 1.39A 2vxaH-1xr4A:
undetectable
2vxaJ-1xr4A:
undetectable
2vxaK-1xr4A:
undetectable		 2vxaH-1xr4A:
12.20
2vxaJ-1xr4A:
12.20
2vxaK-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 ARG A 493
HIS A 140
GLN A 150
ARG A 145
 None
 1.35A 2vxaA-1xr4A:
undetectable
2vxaK-1xr4A:
undetectable
2vxaL-1xr4A:
undetectable		 2vxaA-1xr4A:
12.20
2vxaK-1xr4A:
12.20
2vxaL-1xr4A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		3 / 3 MET A 289
VAL A 281
GLU A 259
 None
 0.85A 3c6gA-1xr4A:
undetectable		 3c6gA-1xr4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 9 LEU A 460
ILE A 250
ILE A 258
VAL A 442
ILE A 440
 None
 1.10A 3d1yB-1xr4A:
undetectable		 3d1yB-1xr4A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 ILE A 501
GLN A 503
ASN A 383
ILE A 480
PHE A 482
 None
 1.07A 3dzuA-1xr4A:
undetectable		 3dzuA-1xr4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		6 / 12 GLY A 384
VAL A 487
ILE A 128
GLY A 125
VAL A 490
ILE A 501
 None
 1.47A 3jw2B-1xr4A:
undetectable		 3jw2B-1xr4A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A 460
ILE A 250
ILE A 258
VAL A 442
ILE A 440
 None
 1.12A 3mwsB-1xr4A:
undetectable		 3mwsB-1xr4A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.29A 3n62A-1xr4A:
undetectable		 3n62A-1xr4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.31A 3n66B-1xr4A:
undetectable		 3n66B-1xr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 9 GLY A 162
GLU A 202
LEU A 199
LEU A 161
ILE A 214
 None
 1.35A 3nbqA-1xr4A:
undetectable		 3nbqA-1xr4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_1
(METHYLTRANSFERASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 9 SER A 324
GLY A 185
GLU A 341
SER A 213
HIS A  64
 None
 1.47A 3ndiA-1xr4A:
1.6		 3ndiA-1xr4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 VAL A 433
LEU A 449
LEU A 453
ILE A 258
 None
 0.83A 3u5kD-1xr4A:
undetectable		 3u5kD-1xr4A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A 285
ILE A 404
VAL A 362
LEU A 402
LEU A 460
 None
 1.12A 3w67D-1xr4A:
2.3		 3w67D-1xr4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 VAL A 431
LEU A 402
VAL A 281
ILE A 463
VAL A 257
 None
 0.90A 3w68D-1xr4A:
2.3		 3w68D-1xr4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		3 / 3 ASN A 361
LEU A 449
PHE A 264
 None
 0.68A 4dajB-1xr4A:
undetectable		 4dajB-1xr4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		6 / 12 GLY A 384
VAL A 487
ILE A 128
GLY A 125
VAL A 490
ILE A 501
 None
 1.45A 4jecA-1xr4A:
undetectable		 4jecA-1xr4A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 7 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.31A 4kcnB-1xr4A:
undetectable		 4kcnB-1xr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 VAL A 433
LEU A 449
LEU A 453
ILE A 258
 None
 0.82A 4lzrA-1xr4A:
undetectable		 4lzrA-1xr4A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 PHE A 325
GLY A 273
SER A 366
ILE A 303
LEU A 300
 None
 1.02A 4qdjA-1xr4A:
2.9		 4qdjA-1xr4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 GLU A 358
CYH A 357
ALA A 397
HIS A 142
TYR A 347
 None
 1.23A 5arfA-1xr4A:
undetectable		 5arfA-1xr4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 ALA A 389
HIS A  65
HIS A 140
THR A 117
 None
 1.13A 5db5A-1xr4A:
5.3
5db5B-1xr4A:
4.6		 5db5A-1xr4A:
22.41
5db5B-1xr4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 6 ILE A 404
ALA A 407
THR A 406
VAL A 431
 None
 0.89A 5eclD-1xr4A:
undetectable		 5eclD-1xr4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 9 LEU A 460
ILE A 250
ILE A 258
VAL A 442
ILE A 440
 None
 1.09A 5kr2D-1xr4A:
undetectable		 5kr2D-1xr4A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.31A 5vunA-1xr4A:
undetectable		 5vunA-1xr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.30A 5vunB-1xr4A:
undetectable		 5vunB-1xr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.32A 5vuoB-1xr4A:
undetectable		 5vuoB-1xr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 GLY A 174
CYH A 181
GLY A 182
LEU A 333
 None
 0.62A 5vw5A-1xr4A:
undetectable		 5vw5A-1xr4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		3 / 3 SER A 118
HIS A  65
TYR A 186
 None
 0.89A 5y2tA-1xr4A:
0.0		 5y2tA-1xr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 8 SER A 297
ASN A 361
PHE A 268
ASP A 266
 None
 1.33A 6auuB-1xr4A:
undetectable		 6auuB-1xr4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A  96
LEU A  91
LEU A 103
GLY A 131
LEU A 132
 None
 0.95A 6b0cD-1xr4A:
3.3		 6b0cD-1xr4A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 HIS A 142
GLY A 392
ILE A  97
LEU A  96
SER A 118
 None
 0.99A 6c2mA-1xr4A:
undetectable		 6c2mA-1xr4A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		4 / 4 HIS A 393
VAL A 363
LEU A 365
ALA A 397
 None
 1.29A 6d8pB-1xr4A:
undetectable		 6d8pB-1xr4A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A 460
ILE A 250
ILE A 258
VAL A 442
ILE A 440
 None
 1.11A 6difA-1xr4A:
undetectable		 6difA-1xr4A:
10.91