SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xrg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.51A 1oniA-1xrgA:
24.0
1oniB-1xrgA:
23.9		 1oniA-1xrgA:
44.52
1oniB-1xrgA:
44.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.48A 1oniB-1xrgA:
23.9
1oniC-1xrgA:
23.9		 1oniB-1xrgA:
44.52
1oniC-1xrgA:
44.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.46A 1oniA-1xrgA:
24.0
1oniC-1xrgA:
23.9		 1oniA-1xrgA:
44.52
1oniC-1xrgA:
44.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.53A 1oniD-1xrgA:
24.0
1oniE-1xrgA:
24.2		 1oniD-1xrgA:
44.52
1oniE-1xrgA:
44.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.47A 1oniG-1xrgA:
23.8
1oniI-1xrgA:
23.8		 1oniG-1xrgA:
44.52
1oniI-1xrgA:
44.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A  62
ALA A  21
GLN A  33
 None
 0.70A 6gb9A-1xrgA:
undetectable		 6gb9A-1xrgA:
16.41