SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xrs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 8 GLU A 211
ILE A 180
LEU A 233
GLU A 218
ALA A 219
None
1.19A 1a29A-1xrsA:
undetectable
1a29A-1xrsA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 9 GLU A 211
ILE A 180
LEU A 233
GLU A 218
ALA A 219
None
1.18A 1ctrA-1xrsA:
undetectable
1ctrA-1xrsA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 7 GLY A 335
ALA A 324
THR A 295
ILE A 293
None
0.83A 1gtnA-1xrsA:
undetectable
1gtnK-1xrsA:
undetectable
1gtnA-1xrsA:
9.30
1gtnK-1xrsA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 LEU A 105
LEU A 108
PRO A 109
MET A 110
None
0.94A 1hz4A-1xrsA:
1.2
1hz4A-1xrsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 4 GLY A 494
LEU A 240
GLY A 497
ARG A 274
None
1.37A 1j7kA-1xrsA:
2.8
1j7kA-1xrsA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 LEU B 218
GLY B 125
LEU B 203
TYR B 235
None
0.96A 1jlbA-1xrsB:
undetectable
1jlbA-1xrsB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 ARG A 217
GLY A 224
ASP A 221
TYR A 145
None
1.44A 1kf6M-1xrsA:
0.0
1kf6N-1xrsA:
undetectable
1kf6M-1xrsA:
20.95
1kf6N-1xrsA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 ASP B 138
GLY B 136
THR B 134
SER B 127
None
B12  B 800 (-3.5A)
B12  B 800 (-4.2A)
None
0.89A 1n4fA-1xrsB:
undetectable
1n4fA-1xrsB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 5 ASP B 182
LEU B 185
ALA B 252
LEU B 256
None
B12  B 800 (-3.6A)
None
None
1.05A 1nh8A-1xrsB:
undetectable
1nh8A-1xrsB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ALA B 245
ASP B 159
ILE B 158
ILE B 113
None
0.89A 1p7lD-1xrsB:
undetectable
1p7lD-1xrsB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ALA B 245
ASP B 159
ILE B 158
ILE B 113
None
0.90A 1p7lC-1xrsB:
undetectable
1p7lC-1xrsB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ALA B 245
ASP B 159
ILE B 158
ILE B 113
None
0.89A 1rg9B-1xrsB:
undetectable
1rg9B-1xrsB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ALA B 245
ASP B 159
ILE B 158
ILE B 113
None
0.90A 1rg9A-1xrsB:
undetectable
1rg9A-1xrsB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ALA B 245
ASP B 159
ILE B 158
ILE B 113
None
0.89A 1rg9D-1xrsB:
undetectable
1rg9D-1xrsB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ALA B 245
ASP B 159
ILE B 158
ILE B 113
None
0.90A 1rg9C-1xrsB:
undetectable
1rg9C-1xrsB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
3 / 3 PRO A  57
ASP A  52
ASP A  64
None
None
5AD  B 500 ( 4.7A)
0.68A 1sqfA-1xrsA:
undetectable
1sqfA-1xrsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 LEU B 207
ALA B 176
ASP B 236
TYR B 235
None
1.23A 2dpzA-1xrsB:
undetectable
2dpzA-1xrsB:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii;
Acetoanaerobium
sticklandii)
4 / 7 TYR B 146
GLY A 204
THR A 185
TYR A 207
B12  B 800 (-4.2A)
None
None
None
0.97A 2g70A-1xrsB:
2.2
2g70A-1xrsB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii;
Acetoanaerobium
sticklandii)
4 / 7 TYR B 146
GLY A 204
THR A 185
TYR A 207
B12  B 800 (-4.2A)
None
None
None
0.96A 2g70B-1xrsB:
undetectable
2g70B-1xrsB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 5 LEU A 262
ILE A 468
ILE A  22
ALA A  23
None
0.66A 2i2zA-1xrsA:
undetectable
2i2zA-1xrsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 4 LEU A 262
ILE A 468
ILE A  22
ALA A  23
None
0.80A 2i30A-1xrsA:
undetectable
2i30A-1xrsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 VAL A 179
GLN A 401
THR A 396
ILE A 403
ASN A 294
None
1.48A 2vdyA-1xrsA:
undetectable
2vdyA-1xrsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 7 ILE A 285
ALA A 289
VAL A 291
GLY A 249
None
0.69A 2xrzB-1xrsA:
undetectable
2xrzB-1xrsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 7 TYR A 505
VAL A  36
CYH A  43
ILE A  66
None
0.98A 2xz5B-1xrsA:
undetectable
2xz5E-1xrsA:
undetectable
2xz5B-1xrsA:
17.69
2xz5E-1xrsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ILE A  66
TYR A 505
VAL A  36
CYH A  43
None
1.02A 2xz5A-1xrsA:
undetectable
2xz5C-1xrsA:
undetectable
2xz5A-1xrsA:
17.69
2xz5C-1xrsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 THR A 295
GLN A 317
ASP A 260
SER A 316
None
1.40A 2xz5A-1xrsA:
undetectable
2xz5C-1xrsA:
undetectable
2xz5A-1xrsA:
17.69
2xz5C-1xrsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ILE A  66
TYR A 505
VAL A  36
CYH A  43
None
0.97A 2xz5C-1xrsA:
undetectable
2xz5D-1xrsA:
undetectable
2xz5C-1xrsA:
17.69
2xz5D-1xrsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 7 ILE A  66
TYR A 505
VAL A  36
CYH A  43
None
0.98A 2xz5D-1xrsA:
undetectable
2xz5E-1xrsA:
undetectable
2xz5D-1xrsA:
17.69
2xz5E-1xrsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
3 / 3 PHE A 509
ASN A 507
PHE A 281
None
1.02A 2zbuD-1xrsA:
undetectable
2zbuD-1xrsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 TYR A 371
PHE A 340
MET A 342
PHE A 350
None
1.35A 3af3A-1xrsA:
0.0
3af3A-1xrsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 PHE A 323
ALA A 324
PHE A 281
GLY A 287
LEU A 514
None
0.94A 3aobC-1xrsA:
0.0
3aobC-1xrsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 GLY A 249
ILE A 285
ALA A 289
PHE A 509
None
0.88A 3aodA-1xrsA:
undetectable
3aodA-1xrsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 LEU A  72
ASN A  60
PRO A 195
VAL A  63
THR A  37
None
1.27A 3dcjA-1xrsA:
undetectable
3dcjB-1xrsA:
undetectable
3dcjA-1xrsA:
19.08
3dcjB-1xrsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 5 PRO A 488
THR A  35
VAL A 498
GLY A 497
None
1.05A 3elzA-1xrsA:
undetectable
3elzA-1xrsA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 5 GLN A 356
THR A 396
HIS A 404
HIS A 338
None
1.48A 3g1uC-1xrsA:
2.1
3g1uC-1xrsA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 9 GLY B 238
ALA B 237
ASP B 236
ILE B 140
THR B 250
None
None
None
B12  B 800 (-4.8A)
None
1.00A 3gguB-1xrsB:
undetectable
3gguB-1xrsB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 GLY A 224
ALA A 225
ALA A 173
ASP A 221
ILE A 231
None
1.14A 3id6C-1xrsA:
undetectable
3id6C-1xrsA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 THR A 410
ASP A 178
ALA A 177
ILE A 425
GLN A 429
None
1.03A 3id6C-1xrsA:
undetectable
3id6C-1xrsA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 SER A 424
PHE A 392
HIS A 404
ASN A 393
None
1.29A 3lskB-1xrsA:
undetectable
3lskB-1xrsA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 SER A 424
PHE A 392
HIS A 404
ASN A 393
None
1.30A 3lskD-1xrsA:
2.3
3lskD-1xrsA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 THR A 312
LEU A 464
LEU A 465
ILE A 468
None
0.91A 3nbqC-1xrsA:
undetectable
3nbqC-1xrsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 LEU A 477
ALA A  23
THR A  26
GLY A 264
None
0.90A 3ny4A-1xrsA:
undetectable
3ny4A-1xrsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 ILE A 468
LEU A 473
GLY A 484
GLY A 483
THR A 476
None
0.95A 3uq6A-1xrsA:
undetectable
3uq6A-1xrsA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 GLN A 356
ALA A 310
LEU A 314
ALA A 360
ILE A 363
None
1.08A 3ut5D-1xrsA:
undetectable
3ut5D-1xrsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 ILE A 468
LEU A 473
GLY A 484
GLY A 483
THR A 476
None
0.96A 3vaqA-1xrsA:
undetectable
3vaqA-1xrsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 ILE A 468
LEU A 473
GLY A 484
GLY A 483
THR A 476
None
0.97A 3vasA-1xrsA:
undetectable
3vasA-1xrsA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii;
Acetoanaerobium
sticklandii)
5 / 12 TYR B  82
LEU A 409
GLY A 380
VAL B  67
PHE B  78
None
1.03A 4a6dA-1xrsB:
2.8
4a6dA-1xrsB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 TYR A 230
ARG A 217
ASP A 178
LEU A 233
None
1.14A 4ax8A-1xrsA:
undetectable
4ax8A-1xrsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 VAL A 179
GLN A 401
THR A 396
ILE A 403
ASN A 294
None
1.48A 4c49B-1xrsA:
undetectable
4c49B-1xrsA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 GLY A 264
ILE A 265
ARG A 487
THR A 275
None
0.80A 4em2A-1xrsA:
undetectable
4em2A-1xrsA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ASN B 162
ASP A 269
ASP B 138
LEU B 163
None
1.09A 4f8hA-1xrsB:
0.7
4f8hB-1xrsB:
0.7
4f8hA-1xrsB:
21.02
4f8hB-1xrsB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ASN B 162
ASP A 269
ASP B 138
LEU B 163
None
1.10A 4f8hB-1xrsB:
0.7
4f8hC-1xrsB:
0.7
4f8hB-1xrsB:
21.02
4f8hC-1xrsB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ASN B 162
ASP A 269
ASP B 138
LEU B 163
None
1.08A 4f8hD-1xrsB:
undetectable
4f8hE-1xrsB:
undetectable
4f8hD-1xrsB:
21.02
4f8hE-1xrsB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 LEU B 163
ASN B 162
ASP A 269
ASP B 138
None
1.09A 4f8hA-1xrsB:
undetectable
4f8hE-1xrsB:
undetectable
4f8hA-1xrsB:
21.02
4f8hE-1xrsB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 ILE A  30
THR A  26
THR A 295
GLU A 321
GLU A 331
None
1.39A 4i41A-1xrsA:
undetectable
4i41A-1xrsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 ALA B 245
ASP B 159
ILE B 158
ILE B 113
None
0.95A 4ndnD-1xrsB:
undetectable
4ndnD-1xrsB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 4 ALA A 169
VAL A 182
GLY A 160
THR A 159
None
1.05A 4ubeA-1xrsA:
undetectable
4ubeA-1xrsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 11 LEU A 301
GLY A 337
LEU A 336
SER A 316
PHE A 364
None
1.16A 4wnuA-1xrsA:
undetectable
4wnuA-1xrsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 11 LEU A 301
GLY A 337
LEU A 336
SER A 316
PHE A 364
None
1.16A 4wnuC-1xrsA:
0.0
4wnuC-1xrsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 LEU A   5
PRO A 365
PHE A 364
GLU A 321
None
1.02A 5b8iA-1xrsA:
undetectable
5b8iA-1xrsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 7 ASN A 235
VAL A 182
ALA A 158
GLY A 160
None
0.92A 5fpdB-1xrsA:
undetectable
5fpdB-1xrsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 6 PHE A 340
SER A 316
VAL A 313
ASP A 298
None
None
None
PLP  B 801 ( 4.7A)
1.26A 5hesA-1xrsA:
undetectable
5hesA-1xrsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 GLU B 108
SER B 105
GLU B 107
GLU B 102
GLU B  46
None
1.44A 5iqdC-1xrsB:
undetectable
5iqdC-1xrsB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 GLU B 108
SER B 105
GLU B 107
GLU B 102
GLU B  46
None
1.46A 5iqeC-1xrsB:
2.0
5iqeC-1xrsB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 VAL B 135
ASP B 138
THR A  35
ARG A 184
GLY A 264
B12  B 800 (-3.7A)
None
None
PLP  B 801 (-2.9A)
None
1.17A 5m50B-1xrsB:
4.8
5m50B-1xrsB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 12 VAL B 135
ASP B 138
THR A  35
ARG A 184
GLY A 264
B12  B 800 (-3.7A)
None
None
PLP  B 801 (-2.9A)
None
1.24A 5m50E-1xrsB:
4.9
5m50E-1xrsB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 7 LEU A   7
PHE A   9
GLU A  13
ASN A 462
None
0.81A 5n5dA-1xrsA:
undetectable
5n5dA-1xrsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
3 / 3 ARG A 402
PHE A 142
ARG A 232
None
1.14A 5y9yA-1xrsA:
0.0
5y9yA-1xrsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 5 ILE A 442
PHE A 444
ARG A 361
THR A 396
None
1.15A 5z84N-1xrsA:
undetectable
5z84W-1xrsA:
undetectable
5z84N-1xrsA:
21.29
5z84W-1xrsA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii)
3 / 3 ALA B  51
PHE B  79
GLN B  69
None
0.79A 6eceA-1xrsB:
3.1
6eceA-1xrsB:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
3 / 3 LEU A 336
GLY A 296
PHE A 482
None
PLP  B 801 ( 4.3A)
None
0.61A 6exiC-1xrsA:
undetectable
6exiC-1xrsA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 5 ILE A 265
GLN A 279
THR A 275
THR A 476
None
1.12A 6f3mD-1xrsA:
2.1
6f3mD-1xrsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
4 / 8 LYS A  14
ALA A  15
LEU A 465
ALA A 315
None
0.82A 6mdqA-1xrsA:
undetectable
6mdqA-1xrsA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 11 GLY A 296
SER A 316
ALA A 324
ARG A 283
ALA A 261
PLP  B 801 ( 4.3A)
None
None
None
None
1.49A 6qgbA-1xrsA:
0.8
6qgbA-1xrsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii)
5 / 11 GLY A 296
SER A 316
ALA A 324
ARG A 283
ALA A 261
PLP  B 801 ( 4.3A)
None
None
None
None
1.47A 6qgbE-1xrsA:
undetectable
6qgbE-1xrsA:
22.62