SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xs5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 8 LEU A 223
ARG A 227
VAL A  29
LEU A  36
 None
 0.79A 1fiqC-1xs5A:
undetectable		 1fiqC-1xs5A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 6 ILE A 174
ASN A 175
SER A 159
ASN A 116
 None
MET  A 301 (-3.8A)
None
MET  A 301 (-3.6A)
 1.25A 1h7xB-1xs5A:
undetectable		 1h7xB-1xs5A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 6 ILE A 174
ASN A 175
SER A 159
ASN A 116
 None
MET  A 301 (-3.8A)
None
MET  A 301 (-3.6A)
 1.26A 1h7xD-1xs5A:
undetectable		 1h7xD-1xs5A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		5 / 12 ALA A 192
GLY A 190
LEU A 124
ALA A 127
PRO A 195
 None
 1.14A 1mjqC-1xs5A:
undetectable
1mjqD-1xs5A:
undetectable		 1mjqC-1xs5A:
19.42
1mjqD-1xs5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		5 / 12 ALA A 192
GLY A 190
LEU A 124
ALA A 127
PRO A 195
 None
 1.14A 1mjqI-1xs5A:
undetectable
1mjqJ-1xs5A:
undetectable		 1mjqI-1xs5A:
19.42
1mjqJ-1xs5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		5 / 11 LEU A 232
GLY A 239
TYR A 236
ILE A 180
LEU A  22
 None
 1.19A 1p91A-1xs5A:
undetectable		 1p91A-1xs5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 8 GLY A  12
VAL A  39
GLU A  40
ILE A  56
 None
 0.76A 1pk7B-1xs5A:
undetectable		 1pk7B-1xs5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		5 / 12 VAL A  99
ILE A 130
GLY A 128
ALA A 127
LEU A  91
 None
 1.09A 1r9oA-1xs5A:
undetectable		 1r9oA-1xs5A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 7 LEU A  36
VAL A   9
GLY A  10
VAL A 206
 None
 0.91A 1t88A-1xs5A:
undetectable		 1t88A-1xs5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 7 LEU A 124
LEU A 121
LEU A  91
PRO A 111
 None
 0.87A 2vq5B-1xs5A:
undetectable		 2vq5B-1xs5A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 6 TYR A  44
ILE A 110
ASN A 175
LEU A  89
 MET  A 301 (-3.7A)
None
MET  A 301 (-3.8A)
None
 1.35A 2wekB-1xs5A:
undetectable		 2wekB-1xs5A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		3 / 3 ILE A  56
VAL A  39
ARG A  37
 None
 0.64A 3p73A-1xs5A:
undetectable		 3p73A-1xs5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 8 LEU A 223
ARG A 227
VAL A  29
LEU A  36
 None
 0.76A 3uniB-1xs5A:
undetectable		 3uniB-1xs5A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		5 / 10 ALA A 192
LEU A  91
ILE A 110
ALA A 109
ALA A 106
 None
 1.02A 4j14A-1xs5A:
undetectable		 4j14A-1xs5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 5 LEU A  14
VAL A  51
TYR A  44
ARG A 221
 None
None
MET  A 301 (-3.7A)
None
 1.00A 4r7iA-1xs5A:
undetectable		 4r7iA-1xs5A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		4 / 5 GLU A  87
HIS A  85
LEU A 204
VAL A  84
 MET  A 301 (-2.6A)
None
None
None
 1.05A 6bc9A-1xs5A:
undetectable		 6bc9A-1xs5A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xs5 MEMBRANE LIPOPROTEIN
TPN32
(Treponema
pallidum) 		3 / 3 LEU A 184
GLY A 190
PHE A 102
 None
 0.57A 6exiC-1xs5A:
undetectable		 6exiC-1xs5A:
15.25