SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xsa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE
(Homo
sapiens) 		4 / 6 ILE A  70
PRO A  45
ILE A  97
GLY A  12
 None
 0.98A 3n3iA-1xsaA:
undetectable		 3n3iA-1xsaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE
(Homo
sapiens) 		5 / 9 ILE A  78
LEU A 147
LYS A  47
ILE A  15
PHE A  31
 None
 1.41A 3sj4X-1xsaA:
undetectable		 3sj4X-1xsaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE
(Homo
sapiens) 		4 / 7 THR A  95
ILE A  97
THR A  59
GLY A  48
 None
 0.96A 4l39B-1xsaA:
undetectable		 4l39B-1xsaA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE
(Homo
sapiens) 		3 / 3 PRO A  45
LEU A  33
GLN A 132
 None
 0.70A 4pevB-1xsaA:
undetectable		 4pevB-1xsaA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE
(Homo
sapiens) 		4 / 5 ALA A  63
HIS A  49
ALA A  10
GLU A  54
 None
 1.47A 5a06C-1xsaA:
undetectable
5a06D-1xsaA:
undetectable		 5a06C-1xsaA:
19.76
5a06D-1xsaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE
(Homo
sapiens) 		5 / 10 ALA A  68
ILE A  70
GLY A  12
LEU A  13
ALA A 101
 None
 1.33A 5ajqB-1xsaA:
undetectable		 5ajqB-1xsaA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE
(Homo
sapiens) 		4 / 7 ALA A 127
PRO A  45
MET A 136
LEU A  32
 None
 1.07A 5dzkD-1xsaA:
undetectable
5dzkR-1xsaA:
undetectable		 5dzkD-1xsaA:
21.00
5dzkR-1xsaA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE
(Homo
sapiens) 		5 / 10 LEU A  34
GLY A  48
LEU A 112
THR A  64
ALA A  68
 None
 1.06A 5o96G-1xsaA:
undetectable
5o96H-1xsaA:
undetectable		 5o96G-1xsaA:
24.71
5o96H-1xsaA:
24.71