SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		4 / 6 PHE A  68
GLU A   7
GLY A  31
THR A   5
 None
 1.16A 1icuA-1xssA:
undetectable
1icuB-1xssA:
undetectable		 1icuA-1xssA:
21.34
1icuB-1xssA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		4 / 6 THR A   5
PHE A  68
GLU A   7
GLY A  31
 None
 1.16A 1icuC-1xssA:
undetectable
1icuD-1xssA:
undetectable		 1icuC-1xssA:
21.34
1icuD-1xssA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		4 / 6 TYR A  87
GLU A 147
ILE A 121
TYR A 119
 None
None
None
DYG  A  64 ( 4.8A)
 1.13A 1maaB-1xssA:
undetectable
1maaD-1xssA:
undetectable		 1maaB-1xssA:
18.16
1maaD-1xssA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		5 / 11 ILE A 198
ALA A 103
GLY A  16
PHE A  61
VAL A  60
 DYG  A  64 ( 3.7A)
None
None
None
None
 0.88A 2fxdA-1xssA:
undetectable		 2fxdA-1xssA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		5 / 12 GLU A 214
ARG A  66
MET A  14
GLY A  27
LEU A  42
 DYG  A  64 ( 3.7A)
DYG  A  64 ( 2.9A)
None
None
None
 1.08A 2jfaB-1xssA:
undetectable		 2jfaB-1xssA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 HIS A 215
GLU A 214
HIS A 196
 None
DYG  A  64 ( 3.7A)
DYG  A  64 ( 3.5A)
 0.85A 3ba0A-1xssA:
undetectable		 3ba0A-1xssA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		4 / 8 ASN A 105
ILE A 107
PHE A  68
TYR A 119
 DYG  A  64 ( 4.1A)
None
None
DYG  A  64 ( 4.8A)
 1.12A 3ccfB-1xssA:
undetectable		 3ccfB-1xssA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 LEU A  50
PRO A  51
ARG A 122
 None
 0.64A 4klrB-1xssA:
undetectable		 4klrB-1xssA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 ASP A 195
HIS A 219
LYS A 217
 None
 0.76A 4qzuD-1xssA:
undetectable		 4qzuD-1xssA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 VAL A  24
THR A  26
ARG A  13
 None
 0.63A 5b2sB-1xssA:
undetectable		 5b2sB-1xssA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 VAL A  24
THR A  26
ARG A  13
 None
 0.64A 5b2tB-1xssA:
undetectable		 5b2tB-1xssA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 SER A 220
LEU A 156
MET A 149
 None
 0.80A 5ikrB-1xssA:
undetectable		 5ikrB-1xssA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 TYR A 119
TYR A  78
SER A  82
 DYG  A  64 ( 4.8A)
None
None
 0.99A 5iktB-1xssA:
undetectable		 5iktB-1xssA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		4 / 7 GLY A  27
GLY A  29
SER A  30
LYS A 211
 None
 0.84A 5izfA-1xssA:
undetectable		 5izfA-1xssA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		5 / 12 VAL A 160
ASP A 159
GLU A 147
LEU A 164
SER A 145
 None
None
None
None
DYG  A  64 ( 2.5A)
 1.18A 5m5cB-1xssA:
undetectable		 5m5cB-1xssA:
18.71