SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 5 PHE A 114
GLY A  90
THR A 139
PHE A  87
 None
 1.19A 1icuC-1xszA:
undetectable
1icuD-1xszA:
undetectable		 1icuC-1xszA:
21.98
1icuD-1xszA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		3 / 3 PHE A  16
TYR A 326
PRO A  20
 None
 1.15A 1mcnA-1xszA:
undetectable
1mcnB-1xszA:
0.7
1mcnP-1xszA:
undetectable		 1mcnA-1xszA:
21.58
1mcnB-1xszA:
21.58
1mcnP-1xszA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 5 ARG A 293
ASP A  60
ASN A  69
TYR A 278
 None
 1.48A 1nbiA-1xszA:
0.6		 1nbiA-1xszA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 5 ARG A 293
ASP A  60
ASN A  69
TYR A 278
 None
 1.48A 1nbiB-1xszA:
0.0		 1nbiB-1xszA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A 275
LEU A 264
VAL A 241
ILE A 237
ILE A 296
 None
 0.76A 1oipA-1xszA:
undetectable		 1oipA-1xszA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 8 LEU A 183
PHE A 255
LEU A 100
SER A 115
 None
 0.89A 1wrlC-1xszA:
undetectable
1wrlD-1xszA:
undetectable		 1wrlC-1xszA:
12.11
1wrlD-1xszA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 10 LEU A 110
SER A 113
PHE A  94
PHE A  76
THR A  77
 None
 0.91A 1wygA-1xszA:
undetectable		 1wygA-1xszA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 5 PRO A 201
PRO A 101
ILE A 107
GLY A 102
 None
 1.10A 2jkjD-1xszA:
undetectable		 2jkjD-1xszA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 5 PRO A 201
PRO A 101
ILE A 107
GLY A 102
 None
 1.09A 2jkjF-1xszA:
undetectable		 2jkjF-1xszA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 287
ALA A 104
TRP A 251
LEU A 110
THR A 144
 None
 1.46A 2oaxC-1xszA:
undetectable		 2oaxC-1xszA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A  53
ILE A  27
ARG A 109
GLU A  66
LEU A  62
 None
 1.13A 2v0mA-1xszA:
undetectable		 2v0mA-1xszA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A  53
ILE A  27
ARG A 109
GLU A  66
LEU A  62
 None
 1.16A 2v0mD-1xszA:
undetectable		 2v0mD-1xszA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 8 LEU A 219
PHE A 315
ALA A 311
ALA A 312
 None
 0.79A 3ax9B-1xszA:
undetectable		 3ax9B-1xszA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		3 / 3 ASP A 266
ASP A 239
ASP A 306
 None
 0.73A 3douA-1xszA:
undetectable		 3douA-1xszA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 4 ILE A 262
GLN A 105
ILE A 296
LEU A 252
 None
 1.16A 3dzyD-1xszA:
undetectable		 3dzyD-1xszA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		3 / 3 ASN A 229
ASP A 239
ARG A 348
 None
 0.83A 3k13C-1xszA:
undetectable		 3k13C-1xszA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 10 ILE A   5
ASN A  25
ILE A  12
ALA A   8
GLU A  11
 None
 1.06A 3u6tA-1xszA:
undetectable		 3u6tA-1xszA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 7 PHE A 288
ASN A 143
THR A 256
ILE A 107
PHE A 196
 None
 1.32A 4ejjA-1xszA:
undetectable		 4ejjA-1xszA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 5 LEU A 110
PHE A 114
LEU A 100
PHE A 196
 None
 1.24A 5iy5P-1xszA:
undetectable
5iy5W-1xszA:
undetectable		 5iy5P-1xszA:
22.15
5iy5W-1xszA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		3 / 3 LYS A  28
GLN A  70
ASN A  69
 None
 1.08A 5l2tA-1xszA:
undetectable		 5l2tA-1xszA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 6 PHE A 254
LEU A 252
SER A 284
GLY A 257
 None
 1.06A 5o4yF-1xszA:
undetectable		 5o4yF-1xszA:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		3 / 3 ARG A 293
PHE A 254
PHE A 196
 None
 0.98A 6nknC-1xszA:
undetectable
6nknJ-1xszA:
undetectable		 6nknC-1xszA:
19.30
6nknJ-1xszA:
11.93