SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xt0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 8 PHE B  46
ILE B  30
ILE B  27
LYS B  26
 None
 0.89A 1sbrA-1xt0B:
undetectable		 1sbrA-1xt0B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 6 LEU B 134
PHE B 137
ALA B 136
LEU B 166
 None
 0.98A 1ukbA-1xt0B:
undetectable		 1ukbA-1xt0B:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 10 LEU B 194
LEU B  95
SER B  63
LEU B 110
LYS B 106
 None
 1.33A 2ceoB-1xt0B:
undetectable		 2ceoB-1xt0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 7 GLY B 169
GLY B 168
VAL B 126
LEU B 135
 None
 0.77A 2oa1B-1xt0B:
undetectable		 2oa1B-1xt0B:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 10 ILE B   5
ASN B  25
ILE B  12
ALA B   8
GLU B  11
 None
 1.03A 3u6tA-1xt0B:
undetectable		 3u6tA-1xt0B:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		5 / 10 LEU B 183
GLU B 182
SER B 185
THR B 158
ASP B 160
 None
 1.47A 4driB-1xt0B:
1.2		 4driB-1xt0B:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 8 GLU B  11
ILE B  30
GLU B   4
ILE B  24
 None
 0.92A 4mj8A-1xt0B:
undetectable		 4mj8A-1xt0B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 5 LEU B 110
PHE B 114
LEU B 100
PHE B 196
 None
 1.21A 5x1fC-1xt0B:
undetectable
5x1fJ-1xt0B:
undetectable		 5x1fC-1xt0B:
20.18
5x1fJ-1xt0B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN
(Legionella
pneumophila) 		4 / 5 ILE B  24
ALA B  57
LEU B  62
LYS B 106
 None
 1.05A 6dwnA-1xt0B:
0.3		 6dwnA-1xt0B:
15.27