SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DVX_B_DIFB125_2 (TRANSTHYRETIN)	1xt5	VARIABLE REGION-CONTAINING CHITIN-BINDING PROTEIN 3 (Branchiostoma floridae)	4 / 7	LEU A 94 LEU A 24 THR A 9 VAL A 7	None	0.89A	1dvxB-1xt5A: undetectable	1dvxB-1xt5A: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HSH_C_MK1C402_2 (HIV-II PROTEASE)	1xt5	VARIABLE REGION-CONTAINING CHITIN-BINDING PROTEIN 3 (Branchiostoma floridae)	5 / 8	ALA A 124 GLY A 121 ILE A 116 PRO A 37 ILE A 39	None	1.44A	1hshD-1xt5A: undetectable	1hshD-1xt5A: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JTV_A_TESA500_1 (17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1)	1xt5	VARIABLE REGION-CONTAINING CHITIN-BINDING PROTEIN 3 (Branchiostoma floridae)	4 / 8	VAL A 99 LEU A 129 PRO A 101 GLU A 15	None	1.22A	1jtvA-1xt5A: undetectable	1jtvA-1xt5A: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D2T_A_1FLA502_1 (TRANSTHYRETIN)	1xt5	VARIABLE REGION-CONTAINING CHITIN-BINDING PROTEIN 3 (Branchiostoma floridae)	4 / 7	LEU A 94 LEU A 24 THR A 9 VAL A 7	None	0.91A	3d2tA-1xt5A: undetectable	3d2tA-1xt5A: 21.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DVX_B_DIFB125_2","TRANSTHYRETIN","1xt5","VARIABLE REGION-CONTAINING CHITIN-BINDING PROTEIN 3","Branchiostoma floridae",4,"LEU A  94;LEU A  24;THR A   9;VAL A   7","None","0.89A","1dvxB-1xt5A:undetectable","1dvxB-1xt5A:21.68"],["1HSH_C_MK1C402_2","HIV-II PROTEASE;HIV-II PROTEASE","1xt5","VARIABLE REGION-CONTAINING CHITIN-BINDING PROTEIN 3","Branchiostoma floridae",5,"ALA A 124;GLY A 121;ILE A 116;PRO A  37;ILE A  39","None","1.44A","1hshD-1xt5A:undetectable","1hshD-1xt5A:22.48"],["1JTV_A_TESA500_1","17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1","1xt5","VARIABLE REGION-CONTAINING CHITIN-BINDING PROTEIN 3","Branchiostoma floridae",4,"VAL A  99;LEU A 129;PRO A 101;GLU A  15","None","1.22A","1jtvA-1xt5A:undetectable","1jtvA-1xt5A:18.15"],["3D2T_A_1FLA502_1","TRANSTHYRETIN","1xt5","VARIABLE REGION-CONTAINING CHITIN-BINDING PROTEIN 3","Branchiostoma floridae",4,"LEU A  94;LEU A  24;THR A   9;VAL A   7","None","0.91A","3d2tA-1xt5A:undetectable","3d2tA-1xt5A:21.38"]]