SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.33A 1hrkB-1xt8A:
undetectable		 1hrkB-1xt8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 8 LEU A  87
ILE A 219
ARG A  52
ILE A 223
 None
 0.84A 2bu8A-1xt8A:
undetectable		 2bu8A-1xt8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.30A 2hrcA-1xt8A:
undetectable		 2hrcA-1xt8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.37A 2hrcB-1xt8A:
undetectable		 2hrcB-1xt8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.24A 2pnjB-1xt8A:
undetectable		 2pnjB-1xt8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 8 GLU A  56
LEU A  13
LEU A 215
ILE A  53
VAL A 208
 None
 1.36A 2uxpA-1xt8A:
undetectable		 2uxpA-1xt8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 8 LEU A 180
ALA A 140
ALA A  71
PHE A  27
 None
None
CYS  A 401 ( 4.7A)
CYS  A 401 (-4.6A)
 0.88A 2vcvF-1xt8A:
undetectable		 2vcvF-1xt8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 7 LEU A 132
ALA A 114
GLY A 112
PHE A 144
 None
 0.88A 2wq5A-1xt8A:
undetectable		 2wq5A-1xt8A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		3 / 3 PRO A 206
LEU A  49
ARG A  52
 None
 0.80A 3aqiA-1xt8A:
undetectable		 3aqiA-1xt8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.29A 3hcoB-1xt8A:
undetectable		 3hcoB-1xt8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 GLY A  44
MET A 107
PHE A 244
ASN A  89
 None
 0.90A 3uq6B-1xt8A:
undetectable		 3uq6B-1xt8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 8 TYR A  45
TYR A 106
ILE A  24
ILE A  47
 None
 1.04A 4afgD-1xt8A:
0.0
4afgE-1xt8A:
0.0		 4afgD-1xt8A:
23.91
4afgE-1xt8A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 6 ALA A 173
LEU A 132
ASP A 126
GLU A 125
 None
 1.00A 4g24A-1xt8A:
undetectable		 4g24A-1xt8A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 8 ILE A 195
HIS A 176
THR A 138
THR A 139
 None
CYS  A 401 ( 4.7A)
CYS  A 401 (-4.4A)
CYS  A 401 (-3.4A)
 0.86A 4n16A-1xt8A:
undetectable		 4n16A-1xt8A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 ILE A  53
LEU A  49
ASP A 220
GLU A  56
 None
 0.95A 4nkxB-1xt8A:
undetectable		 4nkxB-1xt8A:
21.26