SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xtj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		3 / 3 GLU A 134
GLN A 323
ARG A 326
 None
ADP  A 550 (-3.9A)
None
 0.96A 2w3bB-1xtjA:
1.5		 2w3bB-1xtjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		4 / 5 GLN A 305
ALA A 302
GLN A 298
ILE A 301
 None
 1.24A 2z0aA-1xtjA:
undetectable		 2z0aA-1xtjA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		4 / 8 GLY A  46
ILE A  80
PHE A  99
PHE A 227
 None
 1.05A 3ko0K-1xtjA:
0.0
3ko0S-1xtjA:
0.0		 3ko0K-1xtjA:
13.39
3ko0S-1xtjA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		5 / 9 LEU A 104
PHE A 136
ILE A  60
PHE A  47
TYR A 133
 None
None
None
ADP  A 550 (-4.9A)
None
 1.45A 3oshA-1xtjA:
undetectable		 3oshA-1xtjA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		5 / 11 THR A 389
LEU A 386
ILE A 411
SER A 412
LEU A 400
 None
 1.17A 4lhmA-1xtjA:
undetectable		 4lhmA-1xtjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		5 / 12 MET A 140
VAL A 143
VAL A 100
LEU A 104
VAL A 170
 None
 1.47A 4m11D-1xtjA:
undetectable		 4m11D-1xtjA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		3 / 3 VAL A 238
PHE A 215
ARG A 216
 None
 0.94A 4xr4B-1xtjA:
2.3		 4xr4B-1xtjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		4 / 8 ILE A 194
SER A 228
GLU A 197
CYH A 198
 None
None
MG  A 501 (-4.0A)
None
 1.17A 5dqyA-1xtjA:
undetectable		 5dqyA-1xtjA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		4 / 8 TYR A 371
VAL A 403
LEU A 262
ILE A 411
 None
 0.67A 5v0vA-1xtjA:
undetectable		 5v0vA-1xtjA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		4 / 8 LEU A 161
LEU A 177
GLY A 174
LYS A 183
 None
 0.87A 6ce2A-1xtjA:
undetectable		 6ce2A-1xtjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens) 		3 / 3 LEU A 285
ASN A 361
LEU A 278
 None
 0.67A 6exiA-1xtjA:
2.4		 6exiA-1xtjA:
10.82