SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xtp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 LEU A  68
GLY A  66
VAL A  60
MET A 128
GLN A 165
 None
None
None
SAI  A 401 ( 4.9A)
SAI  A 401 (-4.6A)
 1.43A 1nhzA-1xtpA:
undetectable		 1nhzA-1xtpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 ILE A 164
PHE A 179
THR A 119
LEU A  98
LEU A 112
 None
 1.15A 1og5B-1xtpA:
undetectable		 1og5B-1xtpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 1xtp LMAJ004091AAA
(Leishmania
major) 		3 / 3 ASP A  99
PHE A 194
ASN A 110
 None
 0.73A 1sg9B-1xtpA:
9.9		 1sg9B-1xtpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 8 ALA A 168
ILE A 169
CYH A 100
GLY A 101
PHE A 179
 None
None
None
SAI  A 401 (-3.4A)
None
 1.43A 1sv9A-1xtpA:
undetectable		 1sv9A-1xtpA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 10 ALA A 168
ILE A 169
CYH A 100
GLY A 101
PHE A 179
 None
None
None
SAI  A 401 (-3.4A)
None
 1.43A 2b17A-1xtpA:
undetectable		 2b17A-1xtpA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 PHE A 144
LEU A 121
ILE A 104
ALA A 132
VAL A 141
 None
 0.87A 2g78A-1xtpA:
undetectable		 2g78A-1xtpA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 GLY A 103
MET A 128
MET A 149
TYR A 170
LEU A 171
 SAI  A 401 (-3.2A)
SAI  A 401 ( 4.9A)
SAI  A 401 (-4.4A)
SAI  A 401 (-3.8A)
None
 0.74A 3bxoA-1xtpA:
16.4		 3bxoA-1xtpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1xtp LMAJ004091AAA
(Leishmania
major) 		4 / 8 LEU A 161
ALA A 186
LEU A 187
ILE A 107
 None
None
None
SAI  A 401 (-4.9A)
 0.89A 3cldB-1xtpA:
undetectable		 3cldB-1xtpA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 ARG A 106
GLY A 101
GLY A 103
LEU A 122
SER A 148
 SAI  A 401 (-3.9A)
SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
None
SAI  A 401 (-4.0A)
 0.72A 3kkzA-1xtpA:
15.5		 3kkzA-1xtpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 GLY A 101
GLY A 103
PRO A 124
VAL A 125
GLU A 150
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-3.3A)
 0.33A 3mteB-1xtpA:
9.9		 3mteB-1xtpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 GLY A 101
GLY A 103
PRO A 124
GLU A 150
TRP A  57
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-3.3A)
SAI  A 401 (-3.8A)
 0.91A 3p2kB-1xtpA:
10.0		 3p2kB-1xtpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 GLY A 101
GLY A 103
PRO A 124
VAL A 125
GLU A 150
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-3.3A)
 0.42A 3p2kB-1xtpA:
10.0		 3p2kB-1xtpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		4 / 7 ARG A  83
LEU A 111
LEU A 115
ILE A  86
 None
 0.83A 3s56B-1xtpA:
undetectable		 3s56B-1xtpA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 ARG A 106
GLY A 101
GLY A 103
MET A 149
TYR A 170
 SAI  A 401 (-3.9A)
SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.4A)
SAI  A 401 (-3.8A)
 1.24A 3sxjA-1xtpA:
15.2		 3sxjA-1xtpA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 ARG A 106
GLY A 101
GLY A 103
SER A 148
MET A 149
 SAI  A 401 (-3.9A)
SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.0A)
SAI  A 401 (-4.4A)
 0.95A 3sxjA-1xtpA:
15.2		 3sxjA-1xtpA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 ARG A 106
GLY A 101
GLY A 103
MET A 149
TYR A 170
 SAI  A 401 (-3.9A)
SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.4A)
SAI  A 401 (-3.8A)
 1.24A 3sxjB-1xtpA:
15.3		 3sxjB-1xtpA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 ARG A 106
GLY A 101
GLY A 103
SER A 148
MET A 149
 SAI  A 401 (-3.9A)
SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.0A)
SAI  A 401 (-4.4A)
 0.95A 3sxjB-1xtpA:
15.3		 3sxjB-1xtpA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 ARG A 106
GLY A 101
GLY A 103
MET A 149
TYR A 170
 SAI  A 401 (-3.9A)
SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.4A)
SAI  A 401 (-3.8A)
 1.14A 3t7sC-1xtpA:
15.5		 3t7sC-1xtpA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 ARG A 106
GLY A 101
GLY A 103
SER A 148
MET A 149
 SAI  A 401 (-3.9A)
SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.0A)
SAI  A 401 (-4.4A)
 1.01A 3t7sC-1xtpA:
15.5		 3t7sC-1xtpA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 GLY A 101
GLY A 103
MET A 128
MET A 149
ILE A 107
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 ( 4.9A)
SAI  A 401 (-4.4A)
SAI  A 401 (-4.9A)
 1.09A 4qtuB-1xtpA:
15.5		 4qtuB-1xtpA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 GLY A 101
GLY A 103
MET A 128
MET A 149
ILE A 107
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 ( 4.9A)
SAI  A 401 (-4.4A)
SAI  A 401 (-4.9A)
 1.01A 4qtuD-1xtpA:
15.2		 4qtuD-1xtpA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1xtp LMAJ004091AAA
(Leishmania
major) 		4 / 6 ALA A 252
ARG A  83
GLY A  81
GLU A  80
 None
 0.83A 5btgA-1xtpA:
0.0
5btgB-1xtpA:
1.1
5btgC-1xtpA:
0.0		 5btgA-1xtpA:
19.92
5btgB-1xtpA:
23.67
5btgC-1xtpA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 GLY A 101
SER A 148
GLN A 165
TRP A 166
LEU A 171
 SAI  A 401 (-3.4A)
SAI  A 401 (-4.0A)
SAI  A 401 (-4.6A)
None
None
 0.47A 5ubbA-1xtpA:
32.5		 5ubbA-1xtpA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 12 TYR A  50
GLU A 150
LEU A 224
LEU A 214
ALA A 168
 None
SAI  A 401 (-3.3A)
None
None
None
 1.14A 5v0vA-1xtpA:
undetectable		 5v0vA-1xtpA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1xtp LMAJ004091AAA
(Leishmania
major) 		5 / 10 PHE A 180
SER A 228
GLY A 229
ARG A 231
LEU A 253
 None
 1.35A 5zjiA-1xtpA:
undetectable
5zjiJ-1xtpA:
undetectable		 5zjiA-1xtpA:
16.87
5zjiJ-1xtpA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xtp LMAJ004091AAA
(Leishmania
major) 		4 / 7 ALA A  87
ILE A 107
LEU A 111
ILE A 193
 None
SAI  A 401 (-4.9A)
None
None
 0.79A 6b5vA-1xtpA:
undetectable
6b5vB-1xtpA:
undetectable		 6b5vA-1xtpA:
15.48
6b5vB-1xtpA:
15.48