SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xtt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 4 ILE A 121
MET A 149
VAL A 136
GLY A 102
 None
 1.28A 1e06B-1xttA:
undetectable		 1e06B-1xttA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 7 VAL A 167
LEU A  89
LEU A  32
VAL A 191
 None
 0.83A 1jgsA-1xttA:
undetectable		 1jgsA-1xttA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A  40
GLY A  36
ILE A   6
TYR A   4
LEU A 180
 None
 1.16A 1p91A-1xttA:
2.7		 1p91A-1xttA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 5 MET A 142
ALA A 144
TYR A 202
ILE A 203
ASP A 209
 U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
U5P  A1250 (-4.1A)
 0.47A 1upfA-1xttA:
23.7		 1upfA-1xttA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 7 MET A 142
ALA A 144
TYR A 202
ILE A 203
ASP A 209
 U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
U5P  A1250 (-4.1A)
 0.55A 1upfB-1xttA:
24.2		 1upfB-1xttA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 5 MET A 142
ALA A 144
TYR A 202
ILE A 203
ASP A 209
 U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
U5P  A1250 (-4.1A)
 0.51A 1upfC-1xttA:
24.0		 1upfC-1xttA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 4 MET A 142
ALA A 144
TYR A 202
ILE A 203
 U5P  A1250 (-4.5A)
U5P  A1250 (-3.4A)
U5P  A1250 (-4.4A)
U5P  A1250 (-4.1A)
 0.54A 1upfD-1xttA:
24.7		 1upfD-1xttA:
34.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 6 LEU A 153
VAL A 157
LYS A 158
ILE A 164
ILE A 179
 None
 1.16A 2piwA-1xttA:
undetectable		 2piwA-1xttA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A  75
ALA A 139
LEU A  32
THR A  23
ILE A 203
 None
None
None
None
U5P  A1250 (-4.1A)
 1.22A 3prsA-1xttA:
undetectable		 3prsA-1xttA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  36
GLY A  40
LEU A   3
VAL A 191
ALA A 192
 None
 1.25A 3t7vA-1xttA:
undetectable		 3t7vA-1xttA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		3 / 3 LEU A  47
VAL A 133
ASP A 134
 None
 0.68A 4y8wC-1xttA:
1.2		 4y8wC-1xttA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 211
ARG A 105
ALA A 103
SER A 172
ILE A 203
 None
U5P  A1250 (-3.5A)
None
None
U5P  A1250 (-4.1A)
 1.19A 5ih0A-1xttA:
undetectable		 5ih0A-1xttA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  74
ILE A 164
ILE A 129
VAL A 167
ALA A 139
 None
 1.17A 6ajiA-1xttA:
undetectable		 6ajiA-1xttA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A  28
GLY A 211
ALA A  81
ILE A 169
LEU A  32
 None
None
U5P  A1250 ( 3.7A)
None
None
 1.04A 6dwnD-1xttA:
undetectable		 6dwnD-1xttA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 6 PHE A  28
LEU A  15
LEU A  18
ARG A  19
 None
 1.03A 6e43B-1xttA:
undetectable		 6e43B-1xttA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Sulfolobus
solfataricus) 		4 / 6 PHE A  28
LEU A  15
LEU A  18
ARG A  19
 None
 0.94A 6e43D-1xttA:
undetectable		 6e43D-1xttA:
20.20