SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1xty PEPTIDYL-TRNA
HYDROLASE
(Sulfolobus
solfataricus) 		4 / 5 SER A  33
PRO A 104
GLY A 103
TRP A  42
 None
 1.05A 2y7kB-1xtyA:
undetectable		 2y7kB-1xtyA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1xty PEPTIDYL-TRNA
HYDROLASE
(Sulfolobus
solfataricus) 		3 / 3 VAL A   8
SER A  10
LEU A 120
 None
 0.53A 3n8xA-1xtyA:
undetectable		 3n8xA-1xtyA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 1xty PEPTIDYL-TRNA
HYDROLASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 117
ARG A  70
ILE A  97
ARG A   9
 None
None
None
SO4  A 807 (-2.7A)
 1.46A 3ticA-1xtyA:
undetectable		 3ticA-1xtyA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 1xty PEPTIDYL-TRNA
HYDROLASE
(Sulfolobus
solfataricus) 		4 / 7 ILE A 102
SER A  63
LEU A 117
VAL A  61
 None
 0.84A 3ua5B-1xtyA:
undetectable		 3ua5B-1xtyA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1xty PEPTIDYL-TRNA
HYDROLASE
(Sulfolobus
solfataricus) 		5 / 9 ALA A  26
ALA A  24
SER A  33
LEU A  30
VAL A  31
 None
 1.38A 4or0A-1xtyA:
undetectable		 4or0A-1xtyA:
11.15