SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xtz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 152
ILE A 215
ALA A 183
VAL A 161
 None
 0.98A 1hk1A-1xtzA:
undetectable		 1hk1A-1xtzA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 237
GLY A 121
SER A  46
THR A  78
 None
 1.38A 1icvA-1xtzA:
undetectable
1icvB-1xtzA:
undetectable		 1icvA-1xtzA:
23.60
1icvB-1xtzA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.98A 1muiA-1xtzA:
undetectable		 1muiA-1xtzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 110
ALA A 109
GLY A 235
GLY A 121
LEU A 236
 None
 1.07A 1rjdB-1xtzA:
undetectable		 1rjdB-1xtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.89A 1rl8A-1xtzA:
undetectable		 1rl8A-1xtzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 1.01A 1sduB-1xtzA:
undetectable		 1sduB-1xtzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A  33
TYR A 245
HIS A 263
VAL A 253
 None
 1.06A 1wu8A-1xtzA:
undetectable
1wu8C-1xtzA:
undetectable		 1wu8A-1xtzA:
21.16
1wu8C-1xtzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 144
GLU A  19
ARG A  23
LYS A  22
 None
 1.29A 1yc2A-1xtzA:
2.8
1yc2B-1xtzA:
0.0
1yc2E-1xtzA:
3.2		 1yc2A-1xtzA:
22.15
1yc2B-1xtzA:
22.15
1yc2E-1xtzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.90A 2aquA-1xtzA:
undetectable		 2aquA-1xtzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.86A 2avvB-1xtzA:
undetectable		 2avvB-1xtzA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.89A 2avvE-1xtzA:
undetectable		 2avvE-1xtzA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A 134
VAL A 132
SER A 133
GLU A 233
 None
 0.93A 2v41C-1xtzA:
undetectable
2v41D-1xtzA:
undetectable		 2v41C-1xtzA:
23.93
2v41D-1xtzA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 134
VAL A 132
SER A 133
GLU A 233
 None
 0.98A 2v41E-1xtzA:
undetectable
2v41F-1xtzA:
undetectable		 2v41E-1xtzA:
23.93
2v41F-1xtzA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 172
GLU A 224
SER A 169
 None
 0.87A 2xkkA-1xtzA:
3.2
2xkkC-1xtzA:
3.5		 2xkkA-1xtzA:
17.10
2xkkC-1xtzA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.87A 2z54A-1xtzA:
undetectable		 2z54A-1xtzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 153
ALA A 241
ALA A 143
GLU A 111
THR A 234
 None
 1.11A 3c6gB-1xtzA:
undetectable		 3c6gB-1xtzA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 1.04A 3ekpA-1xtzA:
undetectable		 3ekpA-1xtzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.91A 3ekwB-1xtzA:
undetectable		 3ekwB-1xtzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.93A 3ekyA-1xtzA:
undetectable		 3ekyA-1xtzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.96A 3el1A-1xtzA:
undetectable		 3el1A-1xtzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 210
LEU A 221
ARG A 158
HIS A 182
LEU A 181
 None
 1.45A 3erdB-1xtzA:
undetectable		 3erdB-1xtzA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.96A 3lzsB-1xtzA:
undetectable		 3lzsB-1xtzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.93A 3lzuA-1xtzA:
undetectable		 3lzuA-1xtzA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.82A 3ndwA-1xtzA:
undetectable		 3ndwA-1xtzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.82A 3ndxA-1xtzA:
undetectable		 3ndxA-1xtzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.95A 3nuoB-1xtzA:
undetectable		 3nuoB-1xtzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.95A 3tkwA-1xtzA:
undetectable		 3tkwA-1xtzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.96A 3ttpB-1xtzA:
undetectable		 3ttpB-1xtzA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  34
ASN A  33
THR A 138
ILE A  44
ILE A  42
 None
 1.17A 3ut5B-1xtzA:
undetectable		 3ut5B-1xtzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 123
ALA A 124
GLY A 235
ILE A 119
ILE A 207
 None
 0.88A 4hlaA-1xtzA:
undetectable		 4hlaA-1xtzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 5 ILE A 102
VAL A 132
PHE A  80
CYH A  75
HIS A  39
 None
 1.48A 4rzvA-1xtzA:
undetectable		 4rzvA-1xtzA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 209
LEU A 126
GLY A 121
 None
 0.57A 4xmfA-1xtzA:
undetectable		 4xmfA-1xtzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 CYH A  75
ILE A  74
GLN A  92
ILE A  57
 None
 1.19A 4z4cA-1xtzA:
undetectable		 4z4cA-1xtzA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  52
LYS A  19
LYS A  22
 None
 0.93A 5dbyA-1xtzA:
undetectable		 5dbyA-1xtzA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 140
ALA A 105
ILE A 104
ILE A  57
LEU A  34
 None
 1.04A 5mvmA-1xtzA:
undetectable
5mvmE-1xtzA:
undetectable		 5mvmA-1xtzA:
14.92
5mvmE-1xtzA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 235
ARG A 189
ASP A 209
ASP A 110
 None
 1.03A 5vlmB-1xtzA:
1.7		 5vlmB-1xtzA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 153
ASP A 209
ILE A 163
 None
 0.65A 6dh0B-1xtzA:
undetectable		 6dh0B-1xtzA:
17.79