SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 5 THR A1206
THR A1207
THR A1325
HIS A1116
 None
 1.39A 1d4fB-1xv5A:
3.9		 1d4fB-1xv5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
ALA A1085
ILE A1080
LEU A1100
THR A1086
 None
 1.08A 1ddsB-1xv5A:
2.1		 1ddsB-1xv5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
LEU A1127
ILE A1080
LEU A1100
THR A1086
 None
 1.02A 1ddsB-1xv5A:
2.1		 1ddsB-1xv5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 3 PHE A1321
LEU A1381
MET A1178
 None
 0.88A 1mx1D-1xv5A:
2.7		 1mx1D-1xv5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 11 LEU A1363
ILE A1346
ARG A1359
PHE A1348
TYR A1291
 None
 1.02A 2bxmA-1xv5A:
undetectable		 2bxmA-1xv5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 10 LEU A1363
ILE A1346
ARG A1359
PHE A1348
TYR A1291
 None
 1.01A 2bxqA-1xv5A:
0.0		 2bxqA-1xv5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 SER A1387
SER A1304
ARG A1303
GLU A1393
 None
None
EDO  A1404 ( 4.6A)
EDO  A1404 (-4.1A)
 0.95A 2cdqB-1xv5A:
undetectable		 2cdqB-1xv5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 8 HIS A1114
SER A1020
ASN A1081
ILE A1005
TYR A1307
 GOL  A2002 (-3.6A)
None
None
None
UDP  A1402 (-4.7A)
 1.49A 2v57A-1xv5A:
undetectable		 2v57A-1xv5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 8 HIS A1114
SER A1020
ASN A1081
ILE A1005
TYR A1307
 GOL  A2002 (-3.6A)
None
None
None
UDP  A1402 (-4.7A)
 1.49A 2v57C-1xv5A:
undetectable		 2v57C-1xv5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 6 LEU A1369
SER A1355
ASP A1352
GLU A1362
 None
 1.03A 2vn1B-1xv5A:
undetectable		 2vn1B-1xv5A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 8 LEU A1363
PHE A1321
ARG A1374
GLY A1313
 None
 0.82A 3b9lA-1xv5A:
undetectable		 3b9lA-1xv5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 3 PHE A1146
TYR A1112
LEU A1119
 None
 0.77A 3keeB-1xv5A:
undetectable		 3keeB-1xv5A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
ALA A1085
ILE A1080
LEU A1100
THR A1086
 None
 1.15A 3ql0A-1xv5A:
undetectable		 3ql0A-1xv5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
LEU A1127
ILE A1080
LEU A1100
THR A1086
 None
 1.05A 3ql0A-1xv5A:
undetectable		 3ql0A-1xv5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 3 PHE A1146
TYR A1112
LEU A1119
 None
 0.79A 3sueB-1xv5A:
undetectable		 3sueB-1xv5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 3 GLN A1394
PHE A1174
TYR A1112
 None
 0.91A 3ucjB-1xv5A:
2.6		 3ucjB-1xv5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 3 GLN A1394
PHE A1174
TYR A1112
 None
 0.97A 3ucjA-1xv5A:
2.4		 3ucjA-1xv5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 3 LYS A1104
PRO A1105
SER A1106
 None
 0.44A 4k50I-1xv5A:
undetectable		 4k50I-1xv5A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 11 ILE A1397
PHE A1138
ILE A1079
ILE A1398
THR A1170
 None
 1.43A 4p68A-1xv5A:
undetectable		 4p68A-1xv5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
LEU A1127
ILE A1080
LEU A1100
THR A1086
 None
 1.04A 4psyA-1xv5A:
2.0		 4psyA-1xv5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 11 ILE A1093
ALA A1085
ILE A1080
LEU A1100
THR A1086
 None
 1.15A 4qlfA-1xv5A:
2.1		 4qlfA-1xv5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 11 ILE A1093
LEU A1127
ILE A1080
LEU A1100
THR A1086
 None
 1.09A 4qlfA-1xv5A:
2.1		 4qlfA-1xv5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
LEU A1127
ILE A1080
LEU A1100
THR A1086
 None
 1.07A 4qlgB-1xv5A:
undetectable		 4qlgB-1xv5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
ALA A1085
ILE A1080
LEU A1100
THR A1086
 None
 1.18A 4rgcA-1xv5A:
undetectable		 4rgcA-1xv5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
LEU A1127
ILE A1080
LEU A1100
THR A1086
 None
 1.09A 4rgcA-1xv5A:
undetectable		 4rgcA-1xv5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
LEU A1127
ILE A1080
LEU A1100
THR A1086
 None
 1.12A 4x5fA-1xv5A:
2.0		 4x5fA-1xv5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		5 / 12 ILE A1093
LEU A1127
ILE A1080
LEU A1100
THR A1086
 None
 1.13A 4x5fB-1xv5A:
2.1		 4x5fB-1xv5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 4 ARG A1204
GLY A1233
GLU A1235
 CME  A1014 (-3.7A)
UDP  A1402 ( 3.9A)
None
 0.44A 4z2dB-1xv5A:
undetectable
4z2dC-1xv5A:
2.4		 4z2dB-1xv5A:
23.12
4z2dC-1xv5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.85A 5bs8A-1xv5A:
undetectable
5bs8C-1xv5A:
undetectable
5bs8D-1xv5A:
undetectable		 5bs8A-1xv5A:
21.61
5bs8C-1xv5A:
21.61
5bs8D-1xv5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.86A 5btdA-1xv5A:
undetectable
5btdB-1xv5A:
undetectable
5btdC-1xv5A:
undetectable		 5btdA-1xv5A:
21.61
5btdB-1xv5A:
21.59
5btdC-1xv5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.83A 5btdA-1xv5A:
undetectable
5btdC-1xv5A:
undetectable
5btdD-1xv5A:
undetectable		 5btdA-1xv5A:
21.61
5btdC-1xv5A:
21.61
5btdD-1xv5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 6 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.91A 5btgA-1xv5A:
undetectable
5btgB-1xv5A:
undetectable
5btgC-1xv5A:
undetectable		 5btgA-1xv5A:
21.61
5btgB-1xv5A:
21.59
5btgC-1xv5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.88A 5btgA-1xv5A:
undetectable
5btgC-1xv5A:
undetectable
5btgD-1xv5A:
undetectable		 5btgA-1xv5A:
21.61
5btgC-1xv5A:
21.61
5btgD-1xv5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 3 SER A1020
LEU A1310
MET A1178
 None
 0.81A 5ikrB-1xv5A:
undetectable		 5ikrB-1xv5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 3 THR A1339
THR A1356
LEU A1293
 None
 0.57A 5m66D-1xv5A:
4.1		 5m66D-1xv5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 8 LEU A1061
PHE A1006
LEU A1100
ILE A1103
 None
 1.01A 5mzjA-1xv5A:
0.0		 5mzjA-1xv5A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ASN A1095
THR A1130
ILE A1093
GLY A1126
 None
 0.95A 5nzyA-1xv5A:
undetectable		 5nzyA-1xv5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 THR A1317
LEU A1312
ILE A1345
TYR A1291
 None
 0.87A 5zsfA-1xv5A:
0.0
5zsfB-1xv5A:
0.0		 5zsfA-1xv5A:
11.25
5zsfB-1xv5A:
11.25