SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.89A 1fm6A-1xv9B:
20.4		 1fm6A-1xv9B:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 1.00A 1fm6U-1xv9B:
20.2		 1fm6U-1xv9B:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.88A 1fm9A-1xv9B:
20.4		 1fm9A-1xv9B:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.89A 1k74A-1xv9B:
20.2		 1k74A-1xv9B:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		3 / 3 ILE B 204
ILE B 201
THR B 208
 None
 0.60A 1rg7A-1xv9B:
undetectable		 1rg7A-1xv9B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.92A 1xiuA-1xv9B:
18.9		 1xiuA-1xv9B:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		4 / 7 GLY B 126
GLN B 171
PHE B 167
PHE B 135
 None
 0.98A 2qmzA-1xv9B:
undetectable
2qmzB-1xv9B:
undetectable		 2qmzA-1xv9B:
20.08
2qmzB-1xv9B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		4 / 7 GLY B 126
GLN B 171
PHE B 167
PHE B 135
 None
 1.04A 2qx4A-1xv9B:
undetectable
2qx4B-1xv9B:
undetectable		 2qx4A-1xv9B:
20.08
2qx4B-1xv9B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		4 / 6 GLY B 126
GLN B 171
PHE B 167
PHE B 135
 None
 1.01A 2qx6A-1xv9B:
undetectable
2qx6B-1xv9B:
undetectable		 2qx6A-1xv9B:
20.08
2qx6B-1xv9B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 9 LEU B 113
LEU B 179
LEU B 267
ALA B 263
PHE B 175
 None
 1.29A 2vcvE-1xv9B:
1.4		 2vcvE-1xv9B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.97A 3oapA-1xv9B:
20.3		 3oapA-1xv9B:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		4 / 7 ARG B 231
GLY B 229
ILE B 226
GLU B 227
 None
 0.92A 4g0vA-1xv9B:
undetectable		 4g0vA-1xv9B:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 VAL B 172
CYH B 202
ASN B 165
LEU B 343
ILE B 346
 None
 1.46A 4kukA-1xv9B:
undetectable		 4kukA-1xv9B:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		4 / 7 GLY B 196
VAL B 169
ILE B 173
VAL B 172
 None
 0.72A 5ik1A-1xv9B:
undetectable		 5ik1A-1xv9B:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 1.01A 5uanA-1xv9B:
19.9		 5uanA-1xv9B:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 11 VAL B 275
GLY B 274
ASP B 271
SER B 192
LEU B 193
 None
 0.99A 5x6yA-1xv9B:
undetectable		 5x6yA-1xv9B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 10 VAL B 275
GLY B 274
ASP B 271
SER B 192
LEU B 193
 None
 1.05A 5x6yB-1xv9B:
undetectable		 5x6yB-1xv9B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 1.03A 5z12C-1xv9B:
19.5		 5z12C-1xv9B:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		5 / 12 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.94A 6a5yD-1xv9B:
20.5		 6a5yD-1xv9B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		4 / 5 LEU B 242
LEU B 206
THR B 225
ARG B 136
 None
 1.09A 6ew0F-1xv9B:
undetectable		 6ew0F-1xv9B:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		4 / 6 LEU B 242
LEU B 206
THR B 225
ARG B 136
 None
 1.09A 6ew0G-1xv9B:
undetectable		 6ew0G-1xv9B:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3
(Homo
sapiens) 		3 / 3 PHE B 135
ARG B 136
GLN B 134
 None
 1.03A 6g1pB-1xv9B:
0.0		 6g1pB-1xv9B:
23.10