SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		4 / 7 LEU A  14
LEU A  19
MET A  54
LEU A  45
 None
 1.01A 1kt3A-1xviA:
undetectable		 1kt3A-1xviA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		5 / 12 GLY A 131
PHE A 178
ALA A 137
THR A 140
ARG A 177
 None
SO4  A 501 (-4.5A)
None
None
SO4  A 501 (-3.0A)
 1.36A 2axnA-1xviA:
undetectable		 2axnA-1xviA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		3 / 3 ALA A 176
GLY A  16
SER A  47
 SO4  A 501 (-3.7A)
None
None
 0.57A 2ivuA-1xviA:
undetectable		 2ivuA-1xviA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		4 / 7 LEU A 170
VAL A 181
VAL A 103
MET A 158
 None
 0.92A 3rgfA-1xviA:
undetectable		 3rgfA-1xviA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		5 / 12 GLN A 171
GLY A  73
GLY A 187
SER A  47
ALA A  74
 None
 1.23A 3t7sA-1xviA:
undetectable		 3t7sA-1xviA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		5 / 12 GLN A 171
GLY A  73
GLY A 187
SER A  47
ALA A  74
 None
 1.23A 3t7sC-1xviA:
undetectable		 3t7sC-1xviA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		4 / 7 PHE A 115
THR A 117
VAL A 181
VAL A 147
 None
 0.99A 4cp4A-1xviA:
undetectable		 4cp4A-1xviA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A  36
LEU A  33
LEU A  61
ALA A  30
GLN A  27
 None
 1.04A 4fn9A-1xviA:
undetectable		 4fn9A-1xviA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A  36
LEU A  33
LEU A  61
ALA A  30
GLN A  27
 None
 1.10A 4ltwA-1xviA:
undetectable		 4ltwA-1xviA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A  48
ALA A  70
VAL A  75
 SO4  A 501 ( 3.9A)
None
None
 0.67A 4o2bC-1xviA:
2.8		 4o2bC-1xviA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		4 / 7 LEU A 222
LEU A 210
ILE A 195
ILE A 196
 None
1PE  A 601 ( 4.4A)
None
None
 0.62A 4ojbA-1xviA:
undetectable		 4ojbA-1xviA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		3 / 3 GLU A  53
THR A 148
HIS A 143
 None
 0.87A 4q15B-1xviA:
undetectable		 4q15B-1xviA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		4 / 6 GLU A  53
ILE A 126
THR A 130
HIS A 143
 None
 0.93A 4qwpA-1xviA:
undetectable		 4qwpA-1xviA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		3 / 3 ARG A  37
GLN A  64
GLU A  80
 None
 0.89A 4tvtA-1xviA:
undetectable		 4tvtA-1xviA:
20.49