SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		5 / 11 GLY A  30
PHE A  33
ALA A  38
PHE A   9
LEU A  12
 None
 0.87A 1ukbA-1xvtA:
2.3		 1ukbA-1xvtA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A 237
CYH A 236
ILE A 281
LEU A 280
LEU A 296
 None
 1.21A 3cs8A-1xvtA:
undetectable		 3cs8A-1xvtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A 181
VAL A  17
TRP A  36
LEU A  12
 None
 0.80A 3v81C-1xvtA:
undetectable		 3v81C-1xvtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 ILE A 196
ASP A 197
ILE A 198
GLY A  26
 None
 0.58A 4ac9C-1xvtA:
3.4		 4ac9C-1xvtA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 ILE A 196
ASP A 197
ILE A 198
GLY A  26
 None
 0.52A 4acaC-1xvtA:
3.2		 4acaC-1xvtA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 ILE A 196
ASP A 197
ILE A 198
GLY A  26
 None
 0.62A 4acbC-1xvtA:
3.5		 4acbC-1xvtA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 5 HIS A  67
VAL A  40
GLU A  39
LYS A   4
 None
 1.30A 4p6vB-1xvtA:
undetectable
4p6vE-1xvtA:
undetectable		 4p6vB-1xvtA:
22.36
4p6vE-1xvtA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A 181
VAL A  17
TRP A  36
LEU A  12
 None
 0.72A 4puoC-1xvtA:
undetectable		 4puoC-1xvtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A 181
VAL A  17
TRP A  36
LEU A  12
 None
 0.86A 4pwdA-1xvtA:
undetectable		 4pwdA-1xvtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A 181
VAL A  17
TRP A  36
LEU A  12
 None
 0.74A 4pwdC-1xvtA:
undetectable		 4pwdC-1xvtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		5 / 11 GLY A 173
ILE A 198
GLY A  21
ILE A  93
PHE A  33
 None
 0.82A 4qoiA-1xvtA:
4.4
4qoiB-1xvtA:
4.4		 4qoiA-1xvtA:
22.60
4qoiB-1xvtA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 5 SER A  20
GLY A  21
GLU A  94
PHE A  92
 COA  A 501 ( 4.0A)
None
None
None
 1.33A 4r82A-1xvtA:
undetectable
4r82B-1xvtA:
undetectable		 4r82A-1xvtA:
20.34
4r82B-1xvtA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A 147
GLY A 125
TYR A 201
ALA A 199
 None
COA  A 501 ( 4.7A)
None
None
 1.14A 4yshB-1xvtA:
4.1		 4yshB-1xvtA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		3 / 3 ASP A 230
ASN A 154
GLN A 153
 None
 0.81A 5k7uA-1xvtA:
undetectable		 5k7uA-1xvtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 161
GLN A 159
ARG A 224
 None
 1.13A 6fn9A-1xvtA:
undetectable		 6fn9A-1xvtA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 161
GLN A 159
ARG A 224
 None
 1.14A 6fnaB-1xvtA:
undetectable		 6fnaB-1xvtA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 161
GLN A 159
ARG A 224
 None
 1.13A 6fnbA-1xvtA:
undetectable		 6fnbA-1xvtA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 ARG A 311
HIS A 303
GLU A 314
GLU A 258
 None
 1.20A 6mn4A-1xvtA:
0.5		 6mn4A-1xvtA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE
(Escherichia
coli) 		4 / 8 ARG A 311
HIS A 303
GLU A 314
GLU A 258
 None
 0.73A 6mn4D-1xvtA:
undetectable		 6mn4D-1xvtA:
20.34