SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 10 ALA A 266
ALA A 102
LEU A  60
VAL A   9
ILE A 252
 None
 1.16A 1claA-1xvxA:
undetectable		 1claA-1xvxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 4 LYS A 166
LEU A 162
ALA A 309
LEU A 305
 None
 1.40A 1f86A-1xvxA:
0.0		 1f86A-1xvxA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 4 LYS A 166
LEU A 162
ALA A 309
LEU A 305
 None
 1.10A 1f86B-1xvxA:
undetectable		 1f86B-1xvxA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 1xvx YFUA
(Yersinia
enterocolitica) 		3 / 3 GLN A  13
TYR A 199
ARG A 200
 None
FE  A 313 (-4.3A)
None
 0.93A 1gtbA-1xvxA:
undetectable		 1gtbA-1xvxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 6 LEU A 127
TRP A 132
PHE A 108
VAL A 194
 None
 1.12A 1ibgH-1xvxA:
undetectable		 1ibgH-1xvxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 8 ASN A  63
ARG A 104
GLY A 142
GLY A  38
 None
FE  A 313 ( 4.0A)
None
ZN  A 314 ( 4.3A)
 0.87A 1jr1B-1xvxA:
undetectable		 1jr1B-1xvxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 1xvx YFUA
(Yersinia
enterocolitica) 		3 / 3 ALA A  66
VAL A  68
TRP A  98
 None
 0.95A 1nrmA-1xvxA:
undetectable		 1nrmA-1xvxA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 1xvx YFUA
(Yersinia
enterocolitica) 		3 / 3 ALA A  66
VAL A  68
TRP A  98
 None
 0.95A 1nrmB-1xvxA:
undetectable		 1nrmB-1xvxA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1xvx YFUA
(Yersinia
enterocolitica) 		3 / 3 ALA A  66
VAL A  68
TRP A  98
 None
 0.80A 1nt6A-1xvxA:
undetectable		 1nt6A-1xvxA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1xvx YFUA
(Yersinia
enterocolitica) 		3 / 3 ALA A  66
VAL A  68
TRP A  98
 None
 0.81A 1nt6B-1xvxA:
undetectable		 1nt6B-1xvxA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 5 GLY A 212
HIS A 197
ASP A 144
ASP A 203
 None
None
FE  A 313 (-2.6A)
None
 1.03A 2oxtB-1xvxA:
undetectable		 2oxtB-1xvxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 8 LEU A 127
VAL A 185
ILE A 115
PHE A 108
 None
 0.94A 2weyB-1xvxA:
undetectable		 2weyB-1xvxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 12 PHE A 227
GLY A 225
ALA A 289
LEU A 287
VAL A 109
 None
 1.03A 3dmhA-1xvxA:
undetectable		 3dmhA-1xvxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 12 LEU A 284
LEU A 287
GLN A 222
TYR A  91
ALA A 226
 None
 1.27A 3gwuA-1xvxA:
undetectable		 3gwuA-1xvxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 12 LEU A 284
LEU A 287
GLN A 222
TYR A  91
ALA A 226
 None
 1.02A 3gwwA-1xvxA:
undetectable		 3gwwA-1xvxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 8 ILE A   7
SER A  20
LEU A  60
VAL A  18
 None
 0.87A 3ua5A-1xvxA:
undetectable		 3ua5A-1xvxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1xvx YFUA
(Yersinia
enterocolitica) 		3 / 3 SER A 141
GLY A 142
GLN A 146
 None
 0.65A 3v4tH-1xvxA:
1.3		 3v4tH-1xvxA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 9 THR A 253
LEU A  60
GLY A 233
VAL A 271
VAL A  87
 None
 1.43A 4c9kB-1xvxA:
undetectable		 4c9kB-1xvxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 9 THR A 253
LEU A  60
GLY A 233
VAL A 271
VAL A  87
 None
 1.38A 4c9pA-1xvxA:
undetectable		 4c9pA-1xvxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 8 SER A 277
LEU A 284
LEU A 287
VAL A 228
 None
None
None
EDO  A 321 (-4.5A)
 0.96A 4oj4A-1xvxA:
undetectable		 4oj4A-1xvxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 9 ALA A 174
PHE A 172
ILE A 148
VAL A 149
GLY A 142
 None
 1.32A 4r20B-1xvxA:
undetectable		 4r20B-1xvxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1xvx YFUA
(Yersinia
enterocolitica) 		3 / 3 SER A 229
TYR A 196
ASP A  40
 None
 0.66A 4rp8C-1xvxA:
undetectable		 4rp8C-1xvxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 5 ILE A 230
PHE A 145
SER A 295
ASP A  40
 None
 1.37A 4rzvB-1xvxA:
undetectable		 4rzvB-1xvxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 9 ASP A  40
LEU A  43
GLY A  44
LEU A  47
LEU A 236
 None
 1.09A 5dqfA-1xvxA:
undetectable		 5dqfA-1xvxA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 6 LYS A 166
LEU A 162
ALA A 309
LEU A 305
 None
 1.04A 5l4iB-1xvxA:
undetectable		 5l4iB-1xvxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 6 ASP A 144
ASP A 203
ARG A 200
ASN A 186
 FE  A 313 (-2.6A)
None
None
None
 1.30A 5l6eA-1xvxA:
undetectable		 5l6eA-1xvxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 12 GLY A 193
ALA A 184
PHE A 145
ALA A 137
TYR A 175
 None
 1.02A 5n5dA-1xvxA:
undetectable		 5n5dA-1xvxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 9 LEU A  60
ALA A  12
GLY A 232
THR A  99
MET A  67
 None
 1.44A 5w5vA-1xvxA:
undetectable		 5w5vA-1xvxA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1xvx YFUA
(Yersinia
enterocolitica) 		5 / 10 GLY A  38
THR A  61
VAL A  70
ALA A  66
LEU A  47
 ZN  A 314 ( 4.3A)
None
None
None
None
 1.09A 6czmA-1xvxA:
5.5
6czmC-1xvxA:
4.3		 6czmA-1xvxA:
21.08
6czmC-1xvxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1xvx YFUA
(Yersinia
enterocolitica) 		4 / 5 ILE A 124
SER A 123
ALA A 160
LEU A 165
 None
 1.02A 6dwnA-1xvxA:
undetectable		 6dwnA-1xvxA:
13.78