SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xvy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.18A 1f86B-1xvyA:
undetectable		 1f86B-1xvyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 6 LEU A 124
TRP A 129
PHE A 105
VAL A 191
 None
 1.18A 1ibgH-1xvyA:
undetectable		 1ibgH-1xvyA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 8 ASN A  60
ARG A 101
GLY A 139
GLY A  35
 None
 0.88A 1jr1B-1xvyA:
undetectable		 1jr1B-1xvyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 5 SER A 226
ASN A  60
ASP A 141
GLU A  59
 None
None
CIT  A 510 ( 4.9A)
CIT  A 510 (-2.6A)
 1.50A 1lqtA-1xvyA:
undetectable
1lqtB-1xvyA:
undetectable		 1lqtA-1xvyA:
23.59
1lqtB-1xvyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 6 TYR A 215
ILE A 192
PRO A 197
PHE A 198
 None
 1.37A 1oniA-1xvyA:
undetectable
1oniC-1xvyA:
undetectable		 1oniA-1xvyA:
20.13
1oniC-1xvyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 6 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.25A 1tyrA-1xvyA:
undetectable		 1tyrA-1xvyA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.33A 2roxA-1xvyA:
undetectable		 2roxA-1xvyA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 10 ALA A 263
LEU A 258
GLU A 265
ILE A 249
LEU A  57
 None
 1.25A 3fl9A-1xvyA:
undetectable		 3fl9A-1xvyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 12 LEU A 281
LEU A 284
GLN A 219
TYR A  88
ALA A 223
 None
 1.29A 3gwuA-1xvyA:
undetectable		 3gwuA-1xvyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 12 LEU A 281
LEU A 284
GLN A 219
TYR A  88
ALA A 223
 None
 1.09A 3gwwA-1xvyA:
undetectable		 3gwwA-1xvyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 6 TRP A 133
PHE A 169
VAL A 187
PRO A 137
 None
 1.30A 3n6dA-1xvyA:
0.4
3n6dB-1xvyA:
0.0		 3n6dA-1xvyA:
20.35
3n6dB-1xvyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 11 GLU A 265
ASN A  60
SER A 228
LEU A  57
LEU A  14
 None
 1.16A 3ndvA-1xvyA:
undetectable
3ndvB-1xvyA:
undetectable		 3ndvA-1xvyA:
22.96
3ndvB-1xvyA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 11 LEU A  14
GLU A 265
ASN A  60
SER A 228
LEU A  57
 None
 1.15A 3ndvA-1xvyA:
undetectable
3ndvB-1xvyA:
0.0		 3ndvA-1xvyA:
22.96
3ndvB-1xvyA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 11 GLU A 265
ASN A  60
SER A 228
LEU A  57
LEU A  14
 None
 1.13A 3ndvC-1xvyA:
0.0
3ndvD-1xvyA:
undetectable		 3ndvC-1xvyA:
22.96
3ndvD-1xvyA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 11 LEU A  14
GLU A 265
ASN A  60
SER A 228
LEU A  57
 None
 1.16A 3ndvC-1xvyA:
0.0
3ndvD-1xvyA:
undetectable		 3ndvC-1xvyA:
22.96
3ndvD-1xvyA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 10 ASP A  37
ASN A 175
SER A 136
TYR A 195
THR A  58
 None
 1.44A 3qg2A-1xvyA:
undetectable		 3qg2A-1xvyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 5 HIS A 238
SER A 236
GLN A 241
VAL A 232
 None
 1.09A 4a99D-1xvyA:
undetectable		 4a99D-1xvyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 9 THR A 250
LEU A  57
GLY A 230
VAL A 268
VAL A  84
 None
 1.44A 4c9kB-1xvyA:
undetectable		 4c9kB-1xvyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 9 THR A 250
LEU A  57
GLY A 230
VAL A 268
VAL A  84
 None
 1.40A 4c9pA-1xvyA:
undetectable		 4c9pA-1xvyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 6 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.05A 4d7bB-1xvyA:
undetectable		 4d7bB-1xvyA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 7 GLY A  21
ASP A  25
GLY A 254
GLU A 256
 None
 0.93A 4koeA-1xvyA:
undetectable
4koeB-1xvyA:
undetectable
4koeD-1xvyA:
undetectable		 4koeA-1xvyA:
23.01
4koeB-1xvyA:
23.01
4koeD-1xvyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 8 SER A 274
LEU A 281
LEU A 284
VAL A 225
 None
 0.93A 4oj4A-1xvyA:
undetectable		 4oj4A-1xvyA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1xvy SFUA
(Yersinia
enterocolitica) 		3 / 3 SER A 226
TYR A 193
ASP A  37
 None
 0.68A 4rp8C-1xvyA:
undetectable		 4rp8C-1xvyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		3 / 3 VAL A 106
LEU A 213
VAL A 104
 None
 0.51A 4wq4A-1xvyA:
undetectable		 4wq4A-1xvyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 12 THR A  58
ALA A   9
ASP A  37
LEU A  32
LEU A  44
 None
 1.25A 4xi3A-1xvyA:
undetectable		 4xi3A-1xvyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 6 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.09A 5a6iA-1xvyA:
undetectable		 5a6iA-1xvyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 9 ASP A  37
LEU A  40
GLY A  41
LEU A  44
LEU A 233
 None
 1.13A 5dqfA-1xvyA:
undetectable		 5dqfA-1xvyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 12 ASP A 290
ALA A 292
GLN A 255
GLY A  97
TYR A  88
 None
 1.25A 5hfjH-1xvyA:
undetectable		 5hfjH-1xvyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 6 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.04A 5l4iA-1xvyA:
undetectable		 5l4iA-1xvyA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 1xvy SFUA
(Yersinia
enterocolitica) 		4 / 6 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.02A 5l4iB-1xvyA:
undetectable		 5l4iB-1xvyA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 12 GLY A 190
ALA A 181
PHE A 142
ALA A 134
TYR A 172
 None
 1.05A 5n5dA-1xvyA:
undetectable		 5n5dA-1xvyA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 12 ASN A  60
LEU A 258
GLY A  97
PHE A  56
ILE A 227
 None
 1.09A 5vooD-1xvyA:
undetectable		 5vooD-1xvyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 12 ASN A  60
LEU A 258
GLY A  97
PHE A  56
ILE A 227
 None
 1.06A 5vooF-1xvyA:
undetectable		 5vooF-1xvyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1xvy SFUA
(Yersinia
enterocolitica) 		3 / 3 ALA A 110
VAL A 106
TYR A 107
 None
 0.70A 5zmqH-1xvyA:
undetectable		 5zmqH-1xvyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1xvy SFUA
(Yersinia
enterocolitica) 		5 / 10 GLY A  35
THR A  58
VAL A  67
ALA A  63
LEU A  44
 None
 1.09A 6czmA-1xvyA:
6.7
6czmC-1xvyA:
5.4		 6czmA-1xvyA:
22.70
6czmC-1xvyA:
22.70