SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 11 ILE C 185
ALA C 189
ASN C 211
PHE C 214
ILE C 230
 None
 1.11A 2aclE-1xwdC:
undetectable		 2aclE-1xwdC:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 8 SER C 226
SER C 201
ASN C 199
GLN C 152
 None
 1.04A 2cmlC-1xwdC:
undetectable		 2cmlC-1xwdC:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 SER C 201
ILE C 225
SER C 226
LEU C 244
ILE C 222
 None
 0.80A 2nnhA-1xwdC:
0.0		 2nnhA-1xwdC:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		3 / 3 PHE C  53
PHE C  66
PHE C  69
 None
 0.73A 2od9A-1xwdC:
undetectable		 2od9A-1xwdC:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		3 / 3 PHE C  53
PHE C  66
PHE C  69
 None
 0.73A 2qqgA-1xwdC:
undetectable		 2qqgA-1xwdC:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 ILE C 185
PHE C 116
PHE C  66
ALA C  65
LEU C 108
 None
 1.33A 2x2nD-1xwdC:
undetectable		 2x2nD-1xwdC:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 PHE C 190
GLY C 192
GLY C 167
LEU C 168
ASN C 163
 None
NAG  C 269 (-3.5A)
None
None
NAG  C 269 (-3.4A)
 1.04A 3av6A-1xwdC:
undetectable		 3av6A-1xwdC:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 6 LEU C 135
ASN C 180
SER C 164
PHE C 190
 None
 1.48A 3i9jB-1xwdC:
undetectable		 3i9jB-1xwdC:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 8 PHE C  91
ALA C  65
PHE C  66
THR C  56
 None
 0.69A 3t3sD-1xwdC:
undetectable		 3t3sD-1xwdC:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 6 LEU C 233
LEU C 209
ILE C 185
THR C 228
 None
 0.91A 4do3B-1xwdC:
undetectable		 4do3B-1xwdC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 7 ILE C 160
PHE C 190
LEU C 177
THR C 228
 None
 1.08A 4mmcA-1xwdC:
undetectable		 4mmcA-1xwdC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 ILE C  77
LEU C 126
ILE C 151
LEU C 108
LEU C  83
 None
 0.95A 4o1zA-1xwdC:
undetectable		 4o1zA-1xwdC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 4 PHE C 190
LEU C 148
LEU C 177
VAL C 173
 None
 1.36A 5xxiA-1xwdC:
undetectable		 5xxiA-1xwdC:
21.65