SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1xwe COMPLEMENT C5
(Homo
sapiens) 		3 / 3 TYR A1619
TYR A1543
GLU A1579
 None
 0.91A 3pfgA-1xweA:
undetectable		 3pfgA-1xweA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1xwe COMPLEMENT C5
(Homo
sapiens) 		4 / 5 GLU A1519
GLU A1520
TYR A1629
GLU A1628
 None
 1.48A 4r87E-1xweA:
undetectable		 4r87E-1xweA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1xwe COMPLEMENT C5
(Homo
sapiens) 		4 / 6 THR A1548
ALA A1561
THR A1562
VAL A1545
 None
 0.92A 5ecoA-1xweA:
undetectable		 5ecoA-1xweA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1xwe COMPLEMENT C5
(Homo
sapiens) 		4 / 7 TYR A1541
LEU A1563
TYR A1619
VAL A1545
 None
 1.24A 6g2pA-1xweA:
undetectable		 6g2pA-1xweA:
17.24