SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		5 / 10 THR A 322
ASN A 319
ASP A 325
VAL A 409
MET A 414
 None
 1.40A 1ivvA-1xwiA:
undetectable		 1ivvA-1xwiA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		5 / 10 THR A 322
ASN A 319
ASP A 325
VAL A 409
MET A 414
 None
 1.40A 1ivvB-1xwiA:
undetectable		 1ivvB-1xwiA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		5 / 12 SER A 201
GLY A 276
PHE A 232
LEU A 219
ILE A 236
 None
 1.29A 1lhuA-1xwiA:
0.0		 1lhuA-1xwiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 289
ARG A 295
ILE A 236
 None
 0.75A 1uobA-1xwiA:
undetectable		 1uobA-1xwiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 279
ASP A 234
ARG A 346
 SO4  A 601 ( 3.5A)
SO4  A 601 ( 4.4A)
None
 0.88A 3k13A-1xwiA:
undetectable		 3k13A-1xwiA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 297
ASN A 279
LEU A 284
LEU A 433
 None
SO4  A 601 ( 3.5A)
None
None
 1.16A 3nk2X-1xwiA:
undetectable		 3nk2X-1xwiA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 300
SER A 337
TYR A 336
ALA A 339
 None
 1.07A 3ravA-1xwiA:
undetectable		 3ravA-1xwiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		4 / 4 ASP A 378
ASP A 379
GLY A 367
THR A 382
 None
 1.40A 3tl9B-1xwiA:
undetectable		 3tl9B-1xwiA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		3 / 3 THR A 256
VAL A 260
GLU A 213
 None
 0.73A 3v4tA-1xwiA:
1.0
3v4tD-1xwiA:
1.1		 3v4tA-1xwiA:
24.33
3v4tD-1xwiA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		4 / 7 GLU A 148
LYS A 147
LEU A 146
LEU A 183
 None
 0.76A 4wg0B-1xwiA:
undetectable
4wg0C-1xwiA:
undetectable		 4wg0B-1xwiA:
3.46
4wg0C-1xwiA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 146
ILE A 170
GLY A 276
ILE A 230
LEU A 239
 None
 0.96A 5ycnA-1xwiA:
undetectable		 5ycnA-1xwiA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 288
PHE A 436
LEU A 284
ILE A 199
 None
 0.85A 6b5vA-1xwiA:
undetectable
6b5vC-1xwiA:
undetectable		 6b5vA-1xwiA:
12.42
6b5vC-1xwiA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 288
PHE A 436
LEU A 284
ILE A 199
 None
 0.85A 6b5vA-1xwiA:
0.0
6b5vB-1xwiA:
undetectable		 6b5vA-1xwiA:
12.42
6b5vB-1xwiA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 288
PHE A 436
LEU A 284
ILE A 199
 None
 0.85A 6b5vC-1xwiA:
undetectable
6b5vD-1xwiA:
undetectable		 6b5vC-1xwiA:
12.42
6b5vD-1xwiA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xwi SKD1 PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 288
PHE A 436
LEU A 284
ILE A 199
 None
 0.86A 6b5vB-1xwiA:
undetectable
6b5vD-1xwiA:
undetectable		 6b5vB-1xwiA:
12.42
6b5vD-1xwiA:
12.42