SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 108
GLY A 109
LEU A  41
ALA A  39
ALA A  42
 None
 0.94A 1x7pA-1xwmA:
undetectable
1x7pB-1xwmA:
undetectable		 1x7pA-1xwmA:
22.48
1x7pB-1xwmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 150
ASP A 156
ASP A 214
 None
 0.65A 2igtA-1xwmA:
undetectable		 2igtA-1xwmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 150
ASP A 156
ASP A 214
 None
 0.64A 2igtB-1xwmA:
undetectable		 2igtB-1xwmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A  98
LYS A 102
ILE A 105
GLY A 108
 None
 0.75A 3bjwB-1xwmA:
undetectable		 3bjwB-1xwmA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A  98
LYS A 102
ILE A 105
GLY A 108
 None
 0.79A 3bjwF-1xwmA:
undetectable		 3bjwF-1xwmA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A  98
LYS A 102
ILE A 105
GLY A 108
 None
 0.75A 3bjwH-1xwmA:
1.5		 3bjwH-1xwmA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		5 / 10 ASN A  99
PHE A  96
ALA A  97
THR A  23
ILE A  52
 None
 1.35A 3t3qA-1xwmA:
undetectable		 3t3qA-1xwmA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		4 / 8 VAL A 155
ASP A 156
TYR A 159
ALA A 126
 None
 0.84A 4m48A-1xwmA:
3.1		 4m48A-1xwmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 121
ASP A 115
VAL A 186
ALA A 187
 None
 0.98A 4nkxA-1xwmA:
undetectable		 4nkxA-1xwmA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		4 / 7 ASN A  60
GLU A  57
GLU A  58
GLU A  56
 None
 1.22A 4r87I-1xwmA:
undetectable		 4r87I-1xwmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		4 / 4 ILE A 100
ASN A  99
ILE A  46
VAL A  45
 None
 1.18A 4uy87-1xwmA:
undetectable		 4uy87-1xwmA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 1xwm PHOSPHATE UPTAKE
REGULATOR
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A  24
ILE A  86
ALA A  94
 None
 0.53A 4wnwB-1xwmA:
undetectable		 4wnwB-1xwmA:
17.33