SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Homo
sapiens) 		4 / 4 LEU A  29
ILE A 127
TYR A 119
TYR A 142
 GOL  A 202 (-3.8A)
None
None
None
 1.43A 3vt7A-1xwwA:
undetectable		 3vt7A-1xwwA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Homo
sapiens) 		3 / 3 SER A  43
ALA A  45
VAL A  46
 None
 0.66A 4o2bC-1xwwA:
2.9		 4o2bC-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Homo
sapiens) 		5 / 9 VAL A   8
LEU A  96
SER A 118
LEU A 115
ILE A 127
 None
 1.36A 4ubsA-1xwwA:
undetectable		 4ubsA-1xwwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Homo
sapiens) 		3 / 3 SER A  43
ALA A  45
VAL A  46
 None
 0.57A 4x1iA-1xwwA:
undetectable		 4x1iA-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Homo
sapiens) 		4 / 4 ASN A  15
SER A  54
ALA A  74
VAL A  51
 None
 1.26A 4x1kC-1xwwA:
2.8		 4x1kC-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Homo
sapiens) 		3 / 3 SER A  43
ALA A  45
VAL A  46
 None
 0.38A 4x20C-1xwwA:
2.9		 4x20C-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Homo
sapiens) 		4 / 8 LEU A  89
PHE A  26
ILE A  41
PHE A 152
 None
 0.82A 5eseA-1xwwA:
undetectable		 5eseA-1xwwA:
13.97