SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 8 GLY A 185
HIS A 186
ALA A 192
ILE A 184
 None
 0.83A 1gtnP-1xx4A:
undetectable
1gtnQ-1xx4A:
undetectable		 1gtnP-1xx4A:
17.62
1gtnQ-1xx4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 12 GLY A 141
GLY A 140
LEU A  57
SER A  58
LEU A  97
 None
 0.98A 1ya4C-1xx4A:
2.1		 1ya4C-1xx4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 PHE A 267
SER A 276
LEU A 168
 BAM  A 600 (-3.5A)
None
None
 0.74A 2w1bA-1xx4A:
undetectable		 2w1bA-1xx4A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 12 ALA A 139
GLU A 165
LEU A 193
LYS A 177
ILE A 184
 None
 1.35A 3ia4A-1xx4A:
undetectable		 3ia4A-1xx4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 7 LEU A 124
TYR A 123
VAL A 226
MET A 245
 None
 1.20A 3ik3B-1xx4A:
undetectable		 3ik3B-1xx4A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 8 THR A 197
GLY A 162
LEU A 209
ILE A 184
 None
 0.83A 3nbqC-1xx4A:
undetectable		 3nbqC-1xx4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 LEU A  95
ARG A 257
ASN A 179
 None
 0.76A 3qxvD-1xx4A:
undetectable		 3qxvD-1xx4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 7 ILE A 133
PHE A  49
GLY A 141
LEU A 122
 None
 0.91A 4zdzA-1xx4A:
undetectable		 4zdzA-1xx4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 9 THR A  84
ILE A  82
PHE A  91
LEU A 122
LEU A  69
 None
 1.40A 4ze0A-1xx4A:
undetectable		 4ze0A-1xx4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 8 LEU A 124
GLU A 117
ARG A 257
LEU A 129
 None
 1.26A 5dxeA-1xx4A:
undetectable		 5dxeA-1xx4A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 7 ALA A 223
VAL A 226
TYR A 150
VAL A 214
HIS A 220
 None
None
None
None
ZN  A 401 (-3.3A)
 1.42A 5ecmD-1xx4A:
0.3		 5ecmD-1xx4A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 11 ILE A  78
GLY A  80
ALA A  45
PHE A  65
VAL A  36
 None
 1.33A 5hw4B-1xx4A:
undetectable		 5hw4B-1xx4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 12 ILE A  78
GLY A  43
SER A 131
ILE A 130
MET A 227
 None
 1.04A 5igvA-1xx4A:
undetectable		 5igvA-1xx4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 6 SER A 243
ASP A 149
GLN A 239
THR A 249
 None
 1.33A 6djzA-1xx4A:
undetectable		 6djzA-1xx4A:
20.82