SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1xx6 THYMIDINE KINASE
(Clostridium
acetobutylicum) 		4 / 8 ARG A  28
VAL A  10
GLU A  11
ILE A 134
 None
 0.84A 1pk7B-1xx6A:
undetectable		 1pk7B-1xx6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1xx6 THYMIDINE KINASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  97
VAL A 101
ALA A 114
CYH A 113
VAL A  10
 None
 1.25A 2g72B-1xx6A:
undetectable		 2g72B-1xx6A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 1xx6 THYMIDINE KINASE
(Clostridium
acetobutylicum) 		3 / 3 ARG A 110
ARG A   3
ILE A 112
 None
 0.93A 4b7qA-1xx6A:
undetectable		 4b7qA-1xx6A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1xx6 THYMIDINE KINASE
(Clostridium
acetobutylicum) 		5 / 12 ASP A  88
ILE A  29
GLN A  37
ALA A  32
ILE A  39
 None
 1.29A 4uroC-1xx6A:
undetectable		 4uroC-1xx6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1xx6 THYMIDINE KINASE
(Clostridium
acetobutylicum) 		4 / 5 ILE A 104
VAL A 111
ILE A  87
VAL A 101
 None
 0.74A 4xdtA-1xx6A:
undetectable		 4xdtA-1xx6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1xx6 THYMIDINE KINASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A 141
GLU A  89
ALA A 152
ILE A 128
MET A 132
 None
 1.41A 5iwuA-1xx6A:
undetectable		 5iwuA-1xx6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1xx6 THYMIDINE KINASE
(Clostridium
acetobutylicum) 		4 / 9 LEU A  25
VAL A  56
SER A  57
ASP A  54
 None
None
ADP  A 301 (-3.1A)
None
 0.90A 6c2mD-1xx6A:
undetectable		 6c2mD-1xx6A:
18.48