SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xx7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA501_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	1xx7	OXETANOCIN-LIKE PROTEIN (Pyrococcus furiosus)	5 / 12	ILE A 40 THR A 41 VAL A 30 ASP A 124 GLU A 71	None None None NI A 201 ( 2.6A) None	1.26A	4i41A-1xx7A: undetectable	4i41A-1xx7A: 18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RVJ_B_478B101_1 (HIV-1 PROTEASE)	1xx7	OXETANOCIN-LIKE PROTEIN (Pyrococcus furiosus)	6 / 11	ASP A 32 VAL A 30 GLY A 18 ILE A 21 THR A 75 ILE A 14	None	1.46A	4rvjA-1xx7A: undetectable	4rvjA-1xx7A: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RVJ_D_478D101_1 (HIV-1 PROTEASE)	1xx7	OXETANOCIN-LIKE PROTEIN (Pyrococcus furiosus)	6 / 11	ASP A 32 VAL A 30 GLY A 18 ILE A 21 THR A 75 ILE A 14	None	1.46A	4rvjC-1xx7A: undetectable	4rvjC-1xx7A: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_D_29SD601_2 (ESTROGEN RECEPTOR)	1xx7	OXETANOCIN-LIKE PROTEIN (Pyrococcus furiosus)	3 / 3	LEU A 11 ASP A 32 ILE A 5	None	0.69A	4xi3D-1xx7A: undetectable	4xi3D-1xx7A: 22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_E_LLLE301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	1xx7	OXETANOCIN-LIKE PROTEIN (Pyrococcus furiosus)	4 / 7	ASP A 124 ARG A 16 GLU A 71 ASP A 76	NI A 201 ( 2.6A) UNX A2019 (-3.1A) None None	1.20A	6mn5E-1xx7A: 0.0	6mn5E-1xx7A: 14.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4I41_A_MIXA501_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","1xx7","OXETANOCIN-LIKE PROTEIN","Pyrococcus furiosus",5,"ILE A  40;THR A  41;VAL A  30;ASP A 124;GLU A  71","None;None;None; NI A 201 ( 2.6A);None","1.26A","4i41A-1xx7A:undetectable","4i41A-1xx7A:18.66"],["4RVJ_B_478B101_1","HIV-1 PROTEASE;HIV-1 PROTEASE","1xx7","OXETANOCIN-LIKE PROTEIN","Pyrococcus furiosus",6,"ASP A  32;VAL A  30;GLY A  18;ILE A  21;THR A  75;ILE A  14","None","1.46A","4rvjA-1xx7A:undetectable","4rvjA-1xx7A:17.58"],["4RVJ_D_478D101_1","HIV-1 PROTEASE;HIV-1 PROTEASE","1xx7","OXETANOCIN-LIKE PROTEIN","Pyrococcus furiosus",6,"ASP A  32;VAL A  30;GLY A  18;ILE A  21;THR A  75;ILE A  14","None","1.46A","4rvjC-1xx7A:undetectable","4rvjC-1xx7A:17.58"],["4XI3_D_29SD601_2","ESTROGEN RECEPTOR","1xx7","OXETANOCIN-LIKE PROTEIN","Pyrococcus furiosus",3,"LEU A  11;ASP A  32;ILE A   5","None","0.69A","4xi3D-1xx7A:undetectable","4xi3D-1xx7A:22.13"],["6MN5_E_LLLE301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","1xx7","OXETANOCIN-LIKE PROTEIN","Pyrococcus furiosus",4,"ASP A 124;ARG A  16;GLU A  71;ASP A  76"," NI A 201 ( 2.6A);UNX A2019 (-3.1A);None;None","1.20A","6mn5E-1xx7A:0.0","6mn5E-1xx7A:14.67"]]