SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 11 LEU B 250
VAL B 253
ILE B 320
ILE B 325
MET B 313
 None
 1.32A 1gx9A-1xxiB:
undetectable		 1gx9A-1xxiB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 11 LEU B 288
VAL B 253
ILE B 320
ILE B 325
MET B 313
 None
 1.40A 1gx9A-1xxiB:
undetectable		 1gx9A-1xxiB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 11 ALA B  55
GLU B  92
LEU B  90
LYS B 121
ILE B  93
 None
 1.11A 1jomA-1xxiB:
undetectable		 1jomA-1xxiB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		4 / 6 PRO B 361
HIS B 360
LEU B 316
ILE B 320
 None
 1.06A 1sbrA-1xxiB:
undetectable
1sbrB-1xxiB:
undetectable		 1sbrA-1xxiB:
20.97
1sbrB-1xxiB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 LEU B 206
LEU B 203
VAL B 232
GLU B 194
LEU B 191
 None
 1.17A 2bxfA-1xxiB:
3.2		 2bxfA-1xxiB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 LEU B 218
LEU B 203
VAL B 232
GLU B 194
LEU B 191
 None
 1.25A 2bxfB-1xxiB:
3.5		 2bxfB-1xxiB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 11 LEU B 286
LEU B 289
ILE B 334
MET B 256
LEU B 281
 None
 1.13A 2ft9A-1xxiB:
undetectable		 2ft9A-1xxiB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 LEU B 139
PHE B 136
SER B 135
THR B 156
THR B 165
 None
 1.17A 2oipB-1xxiB:
undetectable		 2oipB-1xxiB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 LEU B 139
PHE B 136
SER B 135
THR B 156
THR B 165
 None
 1.21A 2oipC-1xxiB:
undetectable		 2oipC-1xxiB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		4 / 6 LEU B 281
ILE B 268
ARG B 274
ILE B 276
 None
 0.99A 2q8hA-1xxiB:
undetectable		 2q8hA-1xxiB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 LEU B 139
PHE B 136
SER B 135
THR B 156
THR B 165
 None
 1.19A 3hj3A-1xxiB:
undetectable		 3hj3A-1xxiB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 GLY B 242
ALA B 207
ALA B 210
THR B 221
LEU B 220
 None
 1.03A 3p2kA-1xxiB:
undetectable		 3p2kA-1xxiB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 LEU B 353
LEU B 282
LEU B 281
GLY B 287
LEU B 289
 None
 1.17A 4j26A-1xxiB:
undetectable		 4j26A-1xxiB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		3 / 3 LEU B 288
MET B 294
TYR B 328
 None
 0.79A 4p6xG-1xxiB:
undetectable		 4p6xG-1xxiB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		5 / 12 ALA B  95
THR B 157
THR B  52
LEU B 124
ARG B  56
 None
None
ADP  B 802 (-3.7A)
None
None
 1.42A 4z7fC-1xxiB:
undetectable		 4z7fC-1xxiB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xxi DNA POLYMERASE III
SUBUNIT GAMMA
(Escherichia
coli) 		3 / 3 LEU B 354
ASN B 269
LEU B 252
 None
 0.67A 6exiA-1xxiB:
undetectable		 6exiA-1xxiB:
15.51