SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		3 / 3 ASN A 155
PHE A 111
VAL A  98
 None
 0.86A 1kijA-1xxlA:
undetectable		 1kijA-1xxlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		4 / 5 ASP A 115
GLU A 142
LEU A 167
LEU A 218
 None
None
SO4  A 404 (-4.6A)
None
 1.10A 1np1A-1xxlA:
undetectable		 1np1A-1xxlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		6 / 12 ILE A  19
GLY A  20
GLY A  22
GLU A  70
ALA A  87
HIS A  90
 None
 0.47A 2fk8A-1xxlA:
18.6		 2fk8A-1xxlA:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GLU_A_SAMA301_0
(YCGJ)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		12 / 12 GLY A  20
GLY A  22
HIS A  25
THR A  26
ASP A  41
ALA A  42
THR A  43
THR A  68
ALA A  69
GLU A  70
ARG A  85
HIS A  90
 None
None
SO4  A 402 (-4.2A)
None
None
None
None
None
None
None
SO4  A 402 (-3.3A)
None
 0.40A 2gluA-1xxlA:
39.0		 2gluA-1xxlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GLU_B_SAMB302_0
(YCGJ)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA A  97
ARG A  85
ALA A  87
HIS A  90
PHE A  91
 None
SO4  A 402 (-3.3A)
None
None
None
 0.97A 2gluB-1xxlA:
38.8		 2gluB-1xxlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GLU_B_SAMB302_0
(YCGJ)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		11 / 12 GLY A  20
GLY A  22
HIS A  25
THR A  26
ALA A  42
THR A  43
THR A  68
ALA A  69
ARG A  85
ALA A  87
HIS A  90
 None
None
SO4  A 402 (-4.2A)
None
None
None
None
None
SO4  A 402 (-3.3A)
None
None
 0.52A 2gluB-1xxlA:
38.8		 2gluB-1xxlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GLU_B_SAMB302_0
(YCGJ)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		11 / 12 GLY A  20
GLY A  22
THR A  26
ALA A  42
THR A  43
THR A  68
ALA A  69
ARG A  85
ALA A  87
HIS A  90
PHE A  91
 None
None
None
None
None
None
None
SO4  A 402 (-3.3A)
None
None
None
 0.61A 2gluB-1xxlA:
38.8		 2gluB-1xxlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA A  21
ALA A  54
VAL A  59
GLU A  36
THR A  83
 None
 1.11A 3c6gB-1xxlA:
undetectable		 3c6gB-1xxlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		8 / 11 GLY A  20
GLY A  22
ASP A  41
ALA A  42
THR A  43
ALA A  69
GLU A  70
ARG A  85
 None
None
None
None
None
None
None
SO4  A 402 (-3.3A)
 0.72A 3g88A-1xxlA:
16.2		 3g88A-1xxlA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		8 / 11 GLY A  20
GLY A  22
ASP A  41
ALA A  42
THR A  43
ALA A  69
GLU A  70
ARG A  85
 None
None
None
None
None
None
None
SO4  A 402 (-3.3A)
 0.71A 3g88B-1xxlA:
16.2		 3g88B-1xxlA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		8 / 12 GLY A  20
GLY A  22
ASP A  41
ALA A  42
THR A  43
ALA A  69
GLU A  70
ARG A  85
 None
None
None
None
None
None
None
SO4  A 402 (-3.3A)
 0.67A 3g89A-1xxlA:
16.2		 3g89A-1xxlA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		8 / 11 GLY A  20
GLY A  22
ASP A  41
ALA A  42
THR A  43
ALA A  69
GLU A  70
ARG A  85
 None
None
None
None
None
None
None
SO4  A 402 (-3.3A)
 0.66A 3g89B-1xxlA:
16.2		 3g89B-1xxlA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		8 / 12 GLY A  20
GLY A  22
ASP A  41
ALA A  42
THR A  43
ALA A  69
GLU A  70
ARG A  85
 None
None
None
None
None
None
None
SO4  A 402 (-3.3A)
 0.69A 3g8bA-1xxlA:
16.1		 3g8bA-1xxlA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		8 / 12 GLY A  20
GLY A  22
ASP A  41
ALA A  42
THR A  43
ALA A  69
GLU A  70
ARG A  85
 None
None
None
None
None
None
None
SO4  A 402 (-3.3A)
 0.68A 3g8bB-1xxlA:
15.3		 3g8bB-1xxlA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		3 / 3 GLY A  22
GLY A  24
THR A  26
 None
 0.27A 3si7B-1xxlA:
undetectable		 3si7B-1xxlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		3 / 3 ARG A  15
PRO A  73
PHE A  79
 None
 0.97A 3thrC-1xxlA:
16.9		 3thrC-1xxlA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		5 / 12 GLY A  20
GLY A  22
ASP A  41
ALA A  87
HIS A  90
 None
 0.53A 4iv8A-1xxlA:
18.8		 4iv8A-1xxlA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		6 / 12 GLY A  20
ASP A  41
MET A  46
ARG A  85
ALA A  87
HIS A  90
 None
None
None
SO4  A 402 (-3.3A)
None
None
 0.88A 4iv8B-1xxlA:
18.9		 4iv8B-1xxlA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		6 / 12 GLY A  20
GLY A  22
ASP A  41
MET A  46
ALA A  87
HIS A  90
 None
 0.76A 4iv8B-1xxlA:
18.9		 4iv8B-1xxlA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		5 / 12 GLU A  56
ALA A  50
SER A  52
PHE A  64
ARG A  85
 None
None
None
None
SO4  A 402 (-3.3A)
 1.36A 5m54B-1xxlA:
undetectable		 5m54B-1xxlA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1xxl YCGJ PROTEIN
(Bacillus
subtilis) 		4 / 6 LEU A 145
SER A 144
ASP A 125
HIS A 116
 None
 1.20A 5om3A-1xxlA:
undetectable
5om3B-1xxlA:
undetectable		 5om3A-1xxlA:
20.37
5om3B-1xxlA:
11.79