SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ALA A 700
SER A 698
ILE A 691
ILE A 705
 None
 0.99A 1yc5A-1xyzA:
undetectable		 1yc5A-1xyzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN A 687
ILE A 715
MET A 704
 None
 0.82A 2h42C-1xyzA:
undetectable		 2h42C-1xyzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A 583
GLU A 587
ILE A 637
ILE A 749
 None
 0.62A 2xkwA-1xyzA:
undetectable		 2xkwA-1xyzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 559
VAL A 533
CYH A 532
 None
 0.98A 3fbxA-1xyzA:
undetectable		 3fbxA-1xyzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 670
VAL A 701
ILE A 715
ARG A 655
 None
 1.21A 3ik3A-1xyzA:
undetectable		 3ik3A-1xyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 670
VAL A 701
ILE A 715
ARG A 655
 None
 1.26A 3ik3B-1xyzA:
undetectable		 3ik3B-1xyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN A 813
ASN A 726
GLU A 763
 None
 0.93A 3kpdC-1xyzA:
undetectable		 3kpdC-1xyzA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 670
VAL A 701
ILE A 715
ARG A 655
 None
 0.87A 3mssB-1xyzA:
undetectable		 3mssB-1xyzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 674
VAL A 701
ILE A 715
ARG A 655
 None
 1.05A 3mssB-1xyzA:
undetectable		 3mssB-1xyzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 THR A 791
GLY A 717
ASP A 716
SER A 751
 None
 1.40A 4rfqA-1xyzA:
undetectable		 4rfqA-1xyzA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A 834
SER A 554
THR A 531
PHE A 752
 None
 1.00A 4wnvD-1xyzA:
undetectable		 4wnvD-1xyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ALA A 826
ARG A 758
GLY A 812
THR A 807
 None
 0.93A 5btgA-1xyzA:
undetectable
5btgC-1xyzA:
undetectable
5btgD-1xyzA:
undetectable		 5btgA-1xyzA:
20.59
5btgC-1xyzA:
20.59
5btgD-1xyzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 639
TRP A 640
ASN A 687
 None
 1.13A 5dv4A-1xyzA:
undetectable		 5dv4A-1xyzA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN A 661
ASP A 648
GLY A 653
 None
 0.67A 5fctB-1xyzA:
undetectable		 5fctB-1xyzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLY A 653
ILE A 658
TYR A 667
TYR A 686
 None
 1.04A 5iwuA-1xyzA:
undetectable		 5iwuA-1xyzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A 827
ALA A 833
LEU A 834
 None
 0.60A 6ag0C-1xyzA:
10.7		 6ag0C-1xyzA:
11.85