SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1xzn PYRR BIFUNCTIONAL
PROTEIN
([Bacillus]
caldolyticus) 		5 / 12 GLY A 150
ALA A  15
PHE A 148
ASP A 147
ALA A 146
 None
 1.12A 3id6C-1xznA:
undetectable		 3id6C-1xznA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1xzn PYRR BIFUNCTIONAL
PROTEIN
([Bacillus]
caldolyticus) 		5 / 12 ALA A  15
PHE A 148
ASP A 147
ALA A 146
VAL A 133
 None
 1.09A 3nvkI-1xznA:
undetectable		 3nvkI-1xznA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1xzn PYRR BIFUNCTIONAL
PROTEIN
([Bacillus]
caldolyticus) 		5 / 12 GLY A 150
ALA A  15
PHE A 148
ALA A 146
VAL A 133
 None
 1.15A 3nvkI-1xznA:
undetectable		 3nvkI-1xznA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1xzn PYRR BIFUNCTIONAL
PROTEIN
([Bacillus]
caldolyticus) 		6 / 12 GLY A 150
ALA A  15
PHE A 148
ASP A 147
ALA A 146
VAL A 133
 None
 1.18A 3nvkF-1xznA:
undetectable
3nvkJ-1xznA:
undetectable		 3nvkF-1xznA:
21.64
3nvkJ-1xznA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1xzn PYRR BIFUNCTIONAL
PROTEIN
([Bacillus]
caldolyticus) 		5 / 8 LEU A  66
GLY A  37
VAL A  36
LEU A 123
MET A 121
 None
 1.28A 4zauA-1xznA:
undetectable		 4zauA-1xznA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1xzn PYRR BIFUNCTIONAL
PROTEIN
([Bacillus]
caldolyticus) 		5 / 12 GLY A 110
ARG A 111
ASN A 152
LEU A 107
THR A 155
 SO4  A 301 (-3.6A)
None
None
None
None
 1.38A 5fhzA-1xznA:
undetectable		 5fhzA-1xznA:
19.24