SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 4 ILE B  16
LEU A 145
VAL A 126
ILE A 130
 FON  A 451 (-4.1A)
None
None
None
 0.92A 1fm6D-1xzqB:
undetectable		 1fm6D-1xzqB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 10 ASP B  25
ALA B 100
GLU B  74
VAL B  77
VAL B   5
 None
 1.37A 1hk5A-1xzqB:
undetectable		 1hk5A-1xzqB:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 PHE A 113
GLU A 428
GLY A 431
PHE A 434
 None
 1.09A 1icuA-1xzqA:
undetectable
1icuB-1xzqA:
undetectable		 1icuA-1xzqA:
18.86
1icuB-1xzqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 PHE A 434
PHE A 113
GLU A 428
GLY A 431
 None
 1.06A 1icuC-1xzqA:
undetectable
1icuD-1xzqA:
undetectable		 1icuC-1xzqA:
18.86
1icuD-1xzqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 8 VAL A  87
VAL A  62
VAL A  60
LEU A  91
 None
 0.91A 1igxA-1xzqA:
undetectable		 1igxA-1xzqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 PHE A 434
PHE A 113
GLU A 428
GLY A 431
 None
 1.05A 1kqbA-1xzqA:
undetectable
1kqbB-1xzqA:
undetectable		 1kqbA-1xzqA:
19.00
1kqbB-1xzqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 PHE A 434
PHE A 113
GLU A 428
GLY A 431
 None
 1.04A 1kqbC-1xzqA:
undetectable
1kqbD-1xzqA:
undetectable		 1kqbC-1xzqA:
19.00
1kqbD-1xzqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		3 / 3 LEU A 231
LEU A 228
SER A 225
 None
 0.67A 1tlmA-1xzqA:
undetectable		 1tlmA-1xzqA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 5 LEU B  34
GLY B  48
HIS B  47
ILE B  46
 None
None
FON  A 451 (-3.9A)
None
 0.91A 1xf1A-1xzqB:
undetectable		 1xf1A-1xzqB:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 LEU B  34
GLY B  48
HIS B  47
ILE B  46
 None
None
FON  A 451 (-3.9A)
None
 0.87A 1xf1B-1xzqB:
undetectable		 1xf1B-1xzqB:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 12 ALA A 125
GLY A 147
GLY A 148
LEU A 382
LEU A 142
 None
 0.76A 1ya4A-1xzqA:
undetectable		 1ya4A-1xzqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 12 ILE A 383
LEU A 382
ALA A 202
GLY A 378
SER A 379
 None
 1.03A 2a58A-1xzqA:
4.7
2a58B-1xzqA:
4.7		 2a58A-1xzqA:
17.86
2a58B-1xzqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 12 ILE A 383
LEU A 382
ALA A 202
GLY A 378
SER A 379
 None
 1.02A 2a58B-1xzqA:
4.7
2a58C-1xzqA:
4.8		 2a58B-1xzqA:
17.86
2a58C-1xzqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 12 ILE A 383
LEU A 382
ALA A 202
GLY A 378
SER A 379
 None
 1.03A 2a58D-1xzqA:
4.7
2a58E-1xzqA:
4.7		 2a58D-1xzqA:
17.86
2a58E-1xzqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		3 / 3 GLY B  23
GLU B  74
ASP B  25
 None
 0.69A 2b25B-1xzqB:
undetectable		 2b25B-1xzqB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 7 SER A 141
LEU A 138
THR A 136
GLY A 205
 None
 0.93A 2ddwB-1xzqA:
2.7		 2ddwB-1xzqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		3 / 3 ILE A 254
ILE A 367
LEU B  86
 None
 0.52A 2prgA-1xzqA:
undetectable		 2prgA-1xzqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 ASP A 293
ARG A 262
ARG A 210
ILE A 206
 None
 1.18A 2yfbB-1xzqA:
2.0		 2yfbB-1xzqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 12 ILE A 367
LEU A 296
LEU A 232
ILE A 254
LEU A 360
 None
 1.08A 3a50D-1xzqA:
undetectable		 3a50D-1xzqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima;
Thermotoga
maritima) 		5 / 9 GLY B  83
SER A 141
LEU A 138
SER A 137
GLU A 131
 None
 1.07A 3ai9X-1xzqB:
undetectable		 3ai9X-1xzqB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 5 TYR B  65
ARG B  20
ILE A  16
THR A   9
 None
FON  B 118 (-4.5A)
FON  B 118 (-4.3A)
None
 1.15A 3dgqA-1xzqB:
0.0		 3dgqA-1xzqB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 9 ILE A 312
ILE A 316
LYS A 319
GLU A 290
LEU A 286
 None
 1.44A 3f78A-1xzqA:
5.2		 3f78A-1xzqA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 GLN A 390
LEU A 392
GLU A 393
LEU A 199
 None
 0.92A 3h5gA-1xzqA:
undetectable
3h5gC-1xzqA:
undetectable		 3h5gA-1xzqA:
4.56
3h5gC-1xzqA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 LEU A 199
GLN A 390
LEU A 392
GLU A 393
 None
 1.10A 3h5gB-1xzqA:
undetectable
3h5gC-1xzqA:
undetectable		 3h5gB-1xzqA:
4.56
3h5gC-1xzqA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 THR A 371
GLN A 372
TYR A 368
ILE A 256
 None
 1.26A 3peoG-1xzqA:
undetectable		 3peoG-1xzqA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 5 LEU A 425
ASP A 401
GLU A 420
VAL A 163
 None
 1.33A 4nkvA-1xzqA:
undetectable		 4nkvA-1xzqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 ILE A 374
PHE A 375
GLY A 378
LEU A 212
 None
 0.70A 4o8fB-1xzqA:
undetectable		 4o8fB-1xzqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 12 SER A 141
ASP A 128
ILE A 383
SER A 381
ARG A 387
 None
 1.21A 4uroB-1xzqA:
undetectable		 4uroB-1xzqA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 LEU A 160
ILE A 161
LEU A 423
GLU A 420
 None
 0.89A 4w5nA-1xzqA:
4.3		 4w5nA-1xzqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 10 GLY B  83
GLY B  84
GLU A 131
GLY B  12
ILE A 238
 None
 1.01A 5aqfA-1xzqB:
undetectable		 5aqfA-1xzqB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 10 GLY B  83
GLY B  84
GLU A 131
GLY B  12
ILE A 238
 None
 1.02A 5aqfC-1xzqB:
undetectable		 5aqfC-1xzqB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		5 / 10 GLY B  83
GLY B  84
GLU A 131
GLY B  12
ILE A 238
 None
 1.01A 5aqyA-1xzqB:
undetectable		 5aqyA-1xzqB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 ASP A 119
LEU A 120
GLY A 431
PHE A 434
 None
 1.05A 5nooC-1xzqA:
undetectable		 5nooC-1xzqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 ARG A 127
ILE A 206
ASN A 209
ASP A 128
 None
 1.35A 6dhbA-1xzqA:
undetectable		 6dhbA-1xzqA:
11.13