SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 8 ILE A 356
HIS A 400
LEU A 419
VAL A 354
 None
 0.87A 1fslA-1xzwA:
undetectable		 1fslA-1xzwA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 8 ILE A 356
HIS A 400
LEU A 419
VAL A 354
 None
 0.87A 1fslB-1xzwA:
undetectable		 1fslB-1xzwA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		3 / 3 ARG A 183
ASP A   8
ASN A   3
 None
 0.83A 1nbhA-1xzwA:
undetectable		 1nbhA-1xzwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		3 / 3 ARG A 183
ASP A   8
ASN A   3
 None
 0.85A 1nbhD-1xzwA:
undetectable		 1nbhD-1xzwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 6 TYR A 289
TYR A 378
GLU A 307
PRO A 308
 None
 1.37A 1q13A-1xzwA:
undetectable		 1q13A-1xzwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 6 ARG A 274
GLU A 276
PRO A 121
ALA A 242
 None
 1.48A 2ejfB-1xzwA:
undetectable		 2ejfB-1xzwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 7 TYR A 326
SER A 379
ALA A 380
SER A 329
 None
 1.07A 2i91A-1xzwA:
undetectable		 2i91A-1xzwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 7 TYR A 326
SER A 379
ALA A 380
SER A 329
 None
 1.08A 2i91B-1xzwA:
undetectable		 2i91B-1xzwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		3 / 3 ASP A   8
ASP A 140
ASP A   6
 None
 0.79A 2igtB-1xzwA:
undetectable		 2igtB-1xzwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 4 ASP A   8
ASP A 140
ASP A   6
GLY A 366
 None
 0.93A 2igtC-1xzwA:
undetectable		 2igtC-1xzwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		3 / 3 ARG A 241
GLN A 192
PRO A 193
 None
 0.96A 2qhfA-1xzwA:
undetectable		 2qhfA-1xzwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		5 / 12 LEU A 283
ALA A 157
GLY A 162
THR A 224
ILE A 246
 None
 0.90A 3c6gA-1xzwA:
undetectable		 3c6gA-1xzwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 6 LEU A 159
PHE A 319
ILE A 281
PHE A 306
 None
 0.93A 3ko0B-1xzwA:
undetectable		 3ko0B-1xzwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 6 LEU A 159
PHE A 319
ILE A 281
PHE A 306
 None
 0.96A 3ko0S-1xzwA:
undetectable		 3ko0S-1xzwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 8 HIS A  29
GLY A 182
GLY A 162
ASN A 363
 None
None
None
FE  A 429 ( 4.3A)
 0.91A 3v3nB-1xzwA:
undetectable		 3v3nB-1xzwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 8 HIS A  29
GLY A 182
GLY A 162
ASN A 363
 None
None
None
FE  A 429 ( 4.3A)
 0.91A 3v3nC-1xzwA:
undetectable		 3v3nC-1xzwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		5 / 12 LEU A 283
GLY A 133
GLY A 362
LEU A 159
GLY A 130
 None
 1.17A 4blvA-1xzwA:
undetectable		 4blvA-1xzwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		5 / 12 ASP A 360
HIS A 388
GLY A 133
GLY A 321
LEU A 145
 None
 1.15A 4blvB-1xzwA:
undetectable		 4blvB-1xzwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		6 / 11 GLY A  39
GLY A  33
ILE A  42
ASP A  34
GLU A  36
PRO A 118
 None
 1.16A 4dcmA-1xzwA:
undetectable		 4dcmA-1xzwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 8 GLY A 136
ASN A 363
PHE A 160
ILE A 132
 None
FE  A 429 ( 4.3A)
None
None
 0.98A 4j4vC-1xzwA:
undetectable		 4j4vC-1xzwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 7 LEU A 159
VAL A 158
PRO A 193
TYR A 237
 None
 0.77A 4lb2A-1xzwA:
undetectable		 4lb2A-1xzwA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 5 SER A 141
LYS A   1
ASP A   8
ASN A   3
 None
 1.45A 4pclA-1xzwA:
0.0		 4pclA-1xzwA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 7 THR A  72
THR A 224
HIS A 226
SER A  43
 None
 1.13A 4pfjA-1xzwA:
undetectable		 4pfjA-1xzwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		3 / 3 ASN A 168
ASP A 134
GLY A 162
 None
FE  A 429 ( 3.4A)
None
 0.68A 5fctB-1xzwA:
undetectable		 5fctB-1xzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 7 VAL A 282
PHE A 319
ASN A 334
PHE A 310
 None
 0.99A 5hieC-1xzwA:
undetectable		 5hieC-1xzwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 6 TYR A 166
HIS A 324
ILE A 358
TYR A 252
 FE  A 429 ( 4.3A)
FE  A 429 ( 3.9A)
None
None
 1.29A 5ih0A-1xzwA:
undetectable		 5ih0A-1xzwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 4 ASP A 163
HIS A 285
HIS A 322
HIS A 201
 MN  A 430 (-2.6A)
MN  A 430 (-3.3A)
MN  A 430 ( 3.2A)
PO4  A 431 (-3.8A)
 1.48A 5ncdD-1xzwA:
undetectable		 5ncdD-1xzwA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		5 / 12 TYR A 127
LEU A 283
LEU A 159
LEU A 131
ILE A 317
 None
 1.08A 5v0vA-1xzwA:
undetectable		 5v0vA-1xzwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		5 / 12 TYR A 166
GLY A 133
GLY A 136
LEU A 131
ASP A 134
 FE  A 429 ( 4.3A)
None
None
None
FE  A 429 ( 3.4A)
 1.32A 5yn6A-1xzwA:
undetectable		 5yn6A-1xzwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		5 / 12 TYR A 166
GLY A 133
GLY A 136
LEU A 131
ASP A 134
 FE  A 429 ( 4.3A)
None
None
None
FE  A 429 ( 3.4A)
 1.34A 5yniA-1xzwA:
undetectable		 5yniA-1xzwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		5 / 12 TYR A 166
GLY A 133
GLY A 136
LEU A 131
ASP A 134
 FE  A 429 ( 4.3A)
None
None
None
FE  A 429 ( 3.4A)
 1.32A 5ynmA-1xzwA:
undetectable		 5ynmA-1xzwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		6 / 11 PHE A 129
LEU A 131
ILE A 393
PHE A 319
ILE A 281
ILE A 317
 None
 1.44A 6ebzA-1xzwA:
undetectable		 6ebzA-1xzwA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		6 / 11 PHE A 129
LEU A 131
ILE A 393
PHE A 319
ILE A 281
ILE A 317
 None
 1.42A 6ebzB-1xzwA:
undetectable		 6ebzB-1xzwA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		6 / 11 PHE A 129
LEU A 131
ILE A 393
PHE A 319
ILE A 281
ILE A 317
 None
 1.42A 6ebzC-1xzwA:
undetectable		 6ebzC-1xzwA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		6 / 11 PHE A 129
LEU A 131
ILE A 393
PHE A 319
ILE A 281
ILE A 317
 None
 1.41A 6ebzD-1xzwA:
undetectable		 6ebzD-1xzwA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1xzw PURPLE ACID
PHOSPHATASE
(Ipomoea
batatas) 		4 / 7 TRP A 181
HIS A 173
GLU A 202
ASP A 163
 None
None
None
MN  A 430 (-2.6A)
 1.37A 6mn4F-1xzwA:
undetectable		 6mn4F-1xzwA:
19.75