SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 6 LEU A 151
ASN A 203
LYS A 127
ILE A  27
 None
 1.22A 2jn3A-1xzzA:
undetectable		 2jn3A-1xzzA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 5 VAL A 177
VAL A 176
ARG A 170
LYS A 219
 None
None
GOL  A1001 (-4.8A)
None
 1.06A 3rv5A-1xzzA:
undetectable
3rv5B-1xzzA:
undetectable		 3rv5A-1xzzA:
16.37
3rv5B-1xzzA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 12 LEU A 184
ILE A  27
ILE A 163
LEU A  60
LEU A 126
 None
 1.45A 3vw1B-1xzzA:
undetectable		 3vw1B-1xzzA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 7 ILE A  27
LEU A 193
PHE A 161
GLY A 158
 None
 0.96A 4hajA-1xzzA:
undetectable		 4hajA-1xzzA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 8 LEU A 184
VAL A 209
VAL A 134
LEU A  17
 None
 1.01A 4puoC-1xzzA:
undetectable		 4puoC-1xzzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 ASP A 174
ARG A 170
TYR A 117
 None
GOL  A1001 (-4.8A)
None
 0.98A 5a7mA-1xzzA:
undetectable		 5a7mA-1xzzA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 ASP A 174
ARG A 170
TYR A 117
 None
GOL  A1001 (-4.8A)
None
 0.95A 5a7mB-1xzzA:
undetectable		 5a7mB-1xzzA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 6 PHE A  58
SER A 175
VAL A 176
ASP A  13
 None
 1.17A 5hesA-1xzzA:
undetectable		 5hesA-1xzzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 8 TYR A 117
ILE A 220
VAL A 182
ILE A 121
 None
 0.86A 5mzrE-1xzzA:
undetectable		 5mzrE-1xzzA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 1xzz INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 HIS A 226
ASP A  13
HIS A  10
 None
 0.95A 5n1tW-1xzzA:
undetectable		 5n1tW-1xzzA:
21.43