SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 8 ALA A  28
GLY A  38
ILE A   7
ILE A  47
ILE A  50
 None
 0.99A 1hshD-1y0eA:
undetectable		 1hshD-1y0eA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		3 / 3 THR A  43
ASP A  65
SER A  69
 None
 0.74A 2nxeA-1y0eA:
undetectable		 2nxeA-1y0eA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		3 / 3 THR A  43
ASP A  65
SER A  69
 None
 0.79A 2nxeB-1y0eA:
undetectable		 2nxeB-1y0eA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 12 LEU A  97
ALA A 126
GLY A 143
ILE A 142
LEU A 105
 None
 0.96A 2o4nA-1y0eA:
undetectable		 2o4nA-1y0eA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		5 / 11 ARG A 100
LEU A 108
GLY A  60
ILE A  61
ILE A 112
 None
 0.88A 3nu3B-1y0eA:
undetectable		 3nu3B-1y0eA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 7 LEU A  97
ALA A 126
GLY A 143
ILE A 142
 None
 0.82A 3spkB-1y0eA:
undetectable		 3spkB-1y0eA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 VAL A  71
ASP A  94
ALA A 134
PHE A 139
 None
 0.99A 4nedA-1y0eA:
undetectable		 4nedA-1y0eA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 8 LEU A 105
LEU A 108
VAL A 109
ILE A 121
 None
 0.88A 4oj4A-1y0eA:
undetectable		 4oj4A-1y0eA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		3 / 3 LEU A 146
LEU A 166
ASN A 182
 None
None
PO4  A 502 (-4.2A)
 0.54A 4otwA-1y0eA:
undetectable		 4otwA-1y0eA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 7 ARG A  40
GLY A 203
THR A 145
GLU A 180
 None
PO4  A 502 (-3.6A)
None
None
 0.92A 5bs8A-1y0eA:
undetectable
5bs8C-1y0eA:
undetectable
5bs8D-1y0eA:
undetectable		 5bs8A-1y0eA:
16.70
5bs8C-1y0eA:
16.70
5bs8D-1y0eA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 SER A  21
ARG A  40
THR A 145
GLU A 180
 None
 1.08A 5btaA-1y0eA:
undetectable
5btaB-1y0eA:
undetectable
5btaC-1y0eA:
undetectable		 5btaA-1y0eA:
17.22
5btaB-1y0eA:
25.48
5btaC-1y0eA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 ARG A  40
GLY A 203
THR A 145
GLU A 180
 None
PO4  A 502 (-3.6A)
None
None
 0.93A 5btcA-1y0eA:
undetectable
5btcC-1y0eA:
undetectable
5btcD-1y0eA:
undetectable		 5btcA-1y0eA:
17.22
5btcC-1y0eA:
17.22
5btcD-1y0eA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 SER A  21
ARG A  40
THR A 145
GLU A 180
 None
 1.08A 5btcA-1y0eA:
undetectable
5btcC-1y0eA:
undetectable
5btcD-1y0eA:
undetectable		 5btcA-1y0eA:
17.22
5btcC-1y0eA:
17.22
5btcD-1y0eA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 ARG A  40
GLY A 203
THR A 145
GLU A 180
 None
PO4  A 502 (-3.6A)
None
None
 0.90A 5btcA-1y0eA:
undetectable
5btcB-1y0eA:
undetectable
5btcC-1y0eA:
undetectable		 5btcA-1y0eA:
17.22
5btcB-1y0eA:
25.48
5btcC-1y0eA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 6 SER A  21
ARG A  40
THR A 145
GLU A 180
 None
 1.07A 5btcA-1y0eA:
undetectable
5btcB-1y0eA:
undetectable
5btcC-1y0eA:
undetectable		 5btcA-1y0eA:
17.22
5btcB-1y0eA:
25.48
5btcC-1y0eA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 7 ARG A  40
GLY A 203
THR A 145
GLU A 180
 None
PO4  A 502 (-3.6A)
None
None
 0.90A 5btfA-1y0eA:
undetectable
5btfB-1y0eA:
undetectable
5btfC-1y0eA:
undetectable		 5btfA-1y0eA:
17.22
5btfB-1y0eA:
25.48
5btfC-1y0eA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Staphylococcus
aureus) 		4 / 4 VAL A 169
LEU A 166
LEU A 195
ASP A 162
 None
 1.49A 5xv7A-1y0eA:
undetectable		 5xv7A-1y0eA:
16.44