SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 SER A  43
GLU A  44
GLU A  45
 None
 0.58A 1eqbD-1y0uA:
undetectable		 1eqbD-1y0uA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 SER A  43
GLU A  44
GLU A  45
 None
 0.58A 1eqbB-1y0uA:
undetectable		 1eqbB-1y0uA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 LYS A  63
ILE A  34
THR A  81
 None
 0.66A 1rx3A-1y0uA:
undetectable		 1rx3A-1y0uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		5 / 11 VAL A  26
GLY A  68
THR A  81
ILE A  71
ARG A  31
 None
 1.31A 2f9wA-1y0uA:
undetectable
2f9wB-1y0uA:
undetectable		 2f9wA-1y0uA:
19.17
2f9wB-1y0uA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 LYS A  63
ILE A  34
THR A  81
 None
 0.69A 4gh8A-1y0uA:
undetectable		 4gh8A-1y0uA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 TYR A  24
HIS A  61
ARG A  31
 None
 0.68A 4htfA-1y0uA:
undetectable		 4htfA-1y0uA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 7 VAL A  80
ILE A  71
LEU A  53
LEU A  58
 None
 0.77A 4l1wA-1y0uA:
undetectable		 4l1wA-1y0uA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 7 VAL A  80
ILE A  71
LEU A  53
LEU A  58
 None
 0.90A 4xo7A-1y0uA:
undetectable		 4xo7A-1y0uA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 LYS A  63
ARG A  31
HIS A  61
 None
 1.11A 4zbrA-1y0uA:
undetectable		 4zbrA-1y0uA:
10.05