SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 11 HIS A 323
LEU A 216
GLU A 212
ILE A  72
GLU A 213
 ZN  A1002 ( 3.3A)
None
ZN  A1001 (-3.8A)
None
ZN  A1002 ( 2.0A)
 1.39A 1rnrA-1y0yA:
undetectable		 1rnrA-1y0yA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 12 HIS A 323
LEU A 216
GLU A 212
ILE A  72
GLU A 213
 ZN  A1002 ( 3.3A)
None
ZN  A1001 (-3.8A)
None
ZN  A1002 ( 2.0A)
 1.34A 1rnrB-1y0yA:
undetectable		 1rnrB-1y0yA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		4 / 5 ALA A 219
ASN A  51
ILE A  53
ASP A  47
 None
 0.98A 1yc2D-1y0yA:
undetectable		 1yc2D-1y0yA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 8 TYR A 188
VAL A   7
GLY A 257
THR A 258
ALA A 336
 None
 1.29A 2a1hA-1y0yA:
undetectable
2a1hB-1y0yA:
undetectable		 2a1hA-1y0yA:
20.36
2a1hB-1y0yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 10 ILE A  65
ALA A  66
ALA A 233
ALA A 219
ILE A 348
 None
 1.17A 2aclC-1y0yA:
undetectable		 2aclC-1y0yA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 11 ILE A 190
ALA A 186
ASP A 183
ILE A 303
ILE A  65
 None
None
ZN  A1001 ( 4.2A)
None
None
 1.25A 2blaA-1y0yA:
undetectable		 2blaA-1y0yA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 12 GLY A 218
ASN A  51
ALA A 302
THR A 306
ASP A  47
 None
 1.14A 2c49A-1y0yA:
undetectable		 2c49A-1y0yA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 10 TYR A 188
VAL A   7
GLY A 257
THR A 258
ALA A 336
 None
 1.30A 2coiA-1y0yA:
undetectable
2coiB-1y0yA:
undetectable		 2coiA-1y0yA:
20.63
2coiB-1y0yA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 12 ASP A 264
ASP A 182
ILE A 322
ALA A  66
HIS A  68
 None
ZN  A1002 (-2.4A)
None
None
ZN  A1001 ( 3.4A)
 1.44A 2qmjA-1y0yA:
undetectable		 2qmjA-1y0yA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 12 LEU A 191
ALA A  67
ILE A  53
ALA A 194
ILE A 190
 None
 0.86A 2rkfB-1y0yA:
undetectable		 2rkfB-1y0yA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		4 / 6 LEU A  12
LEU A  11
ILE A 185
ARG A 184
 None
 1.04A 2rlfA-1y0yA:
undetectable
2rlfB-1y0yA:
undetectable		 2rlfA-1y0yA:
8.31
2rlfB-1y0yA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		3 / 3 TYR A 188
VAL A   7
THR A 189
 None
 0.86A 2ygnA-1y0yA:
undetectable		 2ygnA-1y0yA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 10 LEU A 191
ALA A  67
ILE A  53
ALA A 194
ILE A 190
 None
 0.90A 3ekpB-1y0yA:
undetectable		 3ekpB-1y0yA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		3 / 3 GLY A  20
TRP A 106
VAL A 161
 None
 0.75A 3n62B-1y0yA:
undetectable		 3n62B-1y0yA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		3 / 3 GLY A  20
TRP A 106
VAL A 161
 None
 0.74A 3n65B-1y0yA:
undetectable		 3n65B-1y0yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		3 / 3 GLY A  20
TRP A 106
VAL A 161
 None
 0.77A 3n66B-1y0yA:
undetectable		 3n66B-1y0yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 10 ILE A 190
ALA A 186
ASP A 183
ILE A 303
ILE A  65
 None
None
ZN  A1001 ( 4.2A)
None
None
 1.31A 3qgtA-1y0yA:
undetectable		 3qgtA-1y0yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		4 / 7 ASP A 182
GLU A 213
HIS A 323
GLU A 212
 ZN  A1002 (-2.4A)
ZN  A1002 ( 2.0A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.8A)
 1.07A 4hvrA-1y0yA:
undetectable		 4hvrA-1y0yA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 12 VAL A 334
VAL A  15
LEU A  12
ALA A 186
LEU A 191
 None
 1.00A 4m11B-1y0yA:
undetectable		 4m11B-1y0yA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		8 / 11 HIS A  68
ASP A 182
GLU A 212
GLU A 213
GLY A 295
GLY A 296
ILE A 322
HIS A 323
 ZN  A1001 ( 3.4A)
ZN  A1002 (-2.4A)
ZN  A1001 (-3.8A)
ZN  A1002 ( 2.0A)
None
None
None
ZN  A1002 ( 3.3A)
 0.85A 4pqaA-1y0yA:
23.4		 4pqaA-1y0yA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		3 / 3 ILE A  65
ILE A  37
MET A 341
 None
 0.63A 5i9yA-1y0yA:
undetectable		 5i9yA-1y0yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 12 ILE A 273
LEU A 315
PHE A 232
ILE A 260
ALA A 259
 None
 1.07A 5j7wD-1y0yA:
undetectable		 5j7wD-1y0yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		4 / 4 LEU A  12
ARG A 184
ILE A 185
PHE A 181
 None
 1.16A 5kirB-1y0yA:
undetectable		 5kirB-1y0yA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		4 / 5 TYR A 288
ASP A 333
PRO A 318
ALA A 336
 None
 1.12A 5otrA-1y0yA:
undetectable		 5otrA-1y0yA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1y0y FRV OPERON PROTEIN
FRVX
(Pyrococcus
horikoshii) 		5 / 8 GLY A  28
LEU A  27
LEU A  74
VAL A 161
GLY A 110
 None
 1.20A 5vkqB-1y0yA:
undetectable
5vkqC-1y0yA:
undetectable		 5vkqB-1y0yA:
12.02
5vkqC-1y0yA:
12.02