SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 11 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 1.00A 1akdA-1y1pA:
undetectable		 1akdA-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 11 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 1.04A 1phgA-1y1pA:
undetectable		 1phgA-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 7 PHE A 214
PHE A  23
SER A 249
ARG A 328
 ACT  A 803 (-4.5A)
None
None
SO4  A 801 (-3.4A)
 0.71A 1rqpB-1y1pA:
undetectable		 1rqpB-1y1pA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 8 PHE A 214
PHE A  23
SER A 249
ARG A 328
 ACT  A 803 (-4.5A)
None
None
SO4  A 801 (-3.4A)
 0.72A 1rqpC-1y1pA:
undetectable		 1rqpC-1y1pA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 8 PHE A 214
PHE A  23
SER A 249
ARG A 328
 ACT  A 803 (-4.5A)
None
None
SO4  A 801 (-3.4A)
 0.70A 1rqpA-1y1pA:
undetectable		 1rqpA-1y1pA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 8 THR A 131
LEU A  32
VAL A  28
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
 0.87A 1t86A-1y1pA:
undetectable		 1t86A-1y1pA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y1P_A_ACTA803_0
(ALDEHYDE REDUCTASE
II)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 4 HIS A  27
GLU A  30
GLN A  31
PHE A 214
 ACT  A 803 (-3.7A)
ACT  A 803 (-4.7A)
ACT  A 803 (-4.3A)
ACT  A 803 (-4.5A)
 0.00A 1y1pA-1y1pA:
63.4		 1y1pA-1y1pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 11 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 0.96A 2a1nA-1y1pA:
undetectable		 2a1nA-1y1pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		3 / 3 ASP A 311
ILE A 318
VAL A 248
 None
 0.67A 2avvD-1y1pA:
undetectable		 2avvD-1y1pA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 10 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 1.11A 2cp4A-1y1pA:
undetectable		 2cp4A-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 6 GLU A  30
ALA A 250
LEU A 337
THR A 209
 ACT  A 803 (-4.7A)
None
None
NMN  A1001 (-3.8A)
 1.07A 2roxB-1y1pA:
undetectable		 2roxB-1y1pA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 8 PHE A 214
PHE A  23
SER A 249
ARG A 328
 ACT  A 803 (-4.5A)
None
None
SO4  A 801 (-3.4A)
 0.66A 2v7uA-1y1pA:
undetectable		 2v7uA-1y1pA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 7 PHE A 214
PHE A  23
SER A 249
ARG A 328
 ACT  A 803 (-4.5A)
None
None
SO4  A 801 (-3.4A)
 0.67A 2v7uB-1y1pA:
undetectable		 2v7uB-1y1pA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		3 / 3 GLY A  12
TYR A  37
SER A  13
 None
 0.74A 2xatA-1y1pA:
undetectable		 2xatA-1y1pA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 10 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
 None
 1.27A 3lxiA-1y1pA:
undetectable		 3lxiA-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 8 ALA A  25
VAL A  28
LEU A  32
LEU A  16
 None
 0.75A 3roxA-1y1pA:
6.0		 3roxA-1y1pA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 8 GLY A  76
ALA A  77
ASP A  71
GLY A 111
THR A  18
 None
 1.40A 3so9A-1y1pA:
undetectable		 3so9A-1y1pA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 9 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
 None
 1.27A 4c9kA-1y1pA:
undetectable		 4c9kA-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 12 THR A 312
LEU A 316
LEU A 319
GLY A 326
ILE A 253
 None
 1.00A 4c9lA-1y1pA:
undetectable		 4c9lA-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 12 THR A 312
LEU A 316
LEU A 319
GLY A 326
ILE A 253
 None
 0.99A 4c9lB-1y1pA:
undetectable		 4c9lB-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 10 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
 None
 1.28A 4c9nB-1y1pA:
undetectable		 4c9nB-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 9 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
 None
 1.26A 4c9pA-1y1pA:
undetectable		 4c9pA-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 10 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
 None
 1.28A 4c9pB-1y1pA:
undetectable		 4c9pB-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 8 SER A 124
GLU A  80
GLY A  41
ARG A  40
 None
 1.05A 4fgzA-1y1pA:
7.0
4fgzB-1y1pA:
6.6		 4fgzA-1y1pA:
20.80
4fgzB-1y1pA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		3 / 3 ILE A  91
MET A  72
ARG A  44
 NMN  A1001 (-4.9A)
AMP  A1002 (-3.5A)
AMP  A1002 ( 3.6A)
 0.86A 4lnwA-1y1pA:
undetectable		 4lnwA-1y1pA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 10 GLY A 221
THR A 212
HIS A  27
SER A  26
LEU A  52
 None
None
ACT  A 803 (-3.7A)
None
None
 1.34A 4yb6C-1y1pA:
undetectable
4yb6F-1y1pA:
undetectable		 4yb6C-1y1pA:
22.19
4yb6F-1y1pA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 10 HIS A  27
SER A  26
LEU A  52
GLY A 221
THR A 212
 ACT  A 803 (-3.7A)
None
None
None
None
 1.32A 4yb6A-1y1pA:
undetectable
4yb6D-1y1pA:
undetectable		 4yb6A-1y1pA:
22.19
4yb6D-1y1pA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 8 ALA A  67
VAL A  69
GLY A  41
ALA A  20
GLY A  19
 None
None
None
None
AMP  A1002 (-3.5A)
 1.44A 4zjzB-1y1pA:
2.1		 4zjzB-1y1pA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 9 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 1.04A 5cp4A-1y1pA:
undetectable		 5cp4A-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 12 LEU A  33
VAL A  17
ILE A  91
ALA A  92
VAL A  28
 None
None
NMN  A1001 (-4.9A)
AMP  A1002 (-3.7A)
None
 0.77A 5j2tC-1y1pA:
5.2		 5j2tC-1y1pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 9 VAL A 129
HIS A  90
LEU A 255
VAL A 248
SER A 249
 None
 1.49A 6c2mD-1y1pA:
undetectable		 6c2mD-1y1pA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 8 LEU A 113
LEU A 116
LEU A 186
ARG A 270
 None
 0.81A 6ce2A-1y1pA:
undetectable		 6ce2A-1y1pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 5 TYR A 208
VAL A 176
PHE A  23
GLY A 225
 None
 1.13A 6hd4A-1y1pA:
undetectable		 6hd4A-1y1pA:
13.40