SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1y1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		3 / 3 ASP A 605
LEU A 606
HIS A 544
 None
 0.77A 1qknA-1y1uA:
undetectable		 1qknA-1y1uA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		4 / 5 SER A 620
SER A 622
THR A 628
ASN A 642
 None
 1.44A 1yvpA-1y1uA:
4.1		 1yvpA-1y1uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		5 / 12 ALA A 414
THR A 351
ALA A 350
ALA A 371
PHE A 444
 None
 1.02A 2gluB-1y1uA:
undetectable		 2gluB-1y1uA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		4 / 7 PHE A 679
LEU A 660
LEU A 666
ARG A 673
 None
 1.04A 2jn3A-1y1uA:
undetectable		 2jn3A-1y1uA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		5 / 9 THR A 481
VAL A 341
ASP A 475
ILE A 469
VAL A 467
 None
 1.47A 2l8mA-1y1uA:
undetectable		 2l8mA-1y1uA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		5 / 11 LEU A 282
ILE A 323
ALA A 326
THR A 329
GLU A 454
 None
 1.12A 2v0mD-1y1uA:
undetectable		 2v0mD-1y1uA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		5 / 12 THR A 158
LEU A 151
ILE A 320
ILE A 286
LEU A 229
 None
 1.25A 3gwxA-1y1uA:
0.0		 3gwxA-1y1uA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		4 / 6 ALA A 487
ASN A 486
LEU A 483
VAL A 482
 None
 1.00A 4g24A-1y1uA:
1.5		 4g24A-1y1uA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		3 / 3 PHE A 488
THR A 569
LEU A 511
 None
 0.71A 4qztA-1y1uA:
undetectable		 4qztA-1y1uA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		4 / 8 ALA A 630
ASN A 529
GLY A 596
SER A 622
 None
 0.84A 4r20A-1y1uA:
undetectable		 4r20A-1y1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		3 / 3 VAL A 468
LEU A 342
VAL A 466
 None
 0.56A 4wq4A-1y1uA:
undetectable		 4wq4A-1y1uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		4 / 4 CYH A 279
LEU A 248
LEU A 327
ALA A 326
 None
 1.14A 5hpuA-1y1uA:
undetectable
5hpuB-1y1uA:
undetectable		 5hpuA-1y1uA:
3.48
5hpuB-1y1uA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		5 / 8 GLY A 394
LEU A 464
VAL A 466
LEU A 397
ILE A 334
 None
 1.16A 5vkqB-1y1uA:
3.3
5vkqC-1y1uA:
3.4		 5vkqB-1y1uA:
15.62
5vkqC-1y1uA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		5 / 12 TYR A 405
LEU A 412
SER A 413
LEU A 355
GLY A 357
 None
 1.01A 5wyqB-1y1uA:
undetectable		 5wyqB-1y1uA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A
(Mus
musculus) 		4 / 5 GLN A 288
ASN A 289
THR A 155
LEU A 151
 None
 1.34A 6d8pA-1y1uA:
undetectable		 6d8pA-1y1uA:
21.19